Results 11 to 20 of about 11,360 (191)

Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post-Kala-Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing. [PDF]

Clin Pharmacol Ther
Post‐kala‐azar dermal leishmaniasis (PKDL) involves a high macrophage burden in which the Leishmania parasites reside. Liposomal amphotericin B (LAmB) plays a key role in the treatment of PKDL. The mononuclear phagocyte system (MPS) is crucial in the distribution of liposomal drugs as well as the leishmaniasis pathophysiology.
Chu WY, Singh OP, Sundar S, Mondal D, Pandey K, Das P, Roseboom IC, Raja S, Torres A, Carrillo E, Huitema ADR, Alves F, Dorlo TPC.   +12 more
europepmc   +2 more sources

Relationship Between Hepcidin, Iron Metabolism, Inflammation and Hypersplenism in Anaemia of Kala-Azar. [PDF]

Parasite Immunol
ABSTRACT Kala‐azar, or visceral leishmaniasis (VL), is a parasitic disease caused by Leishmania spp., characterised by fever, weight loss, splenomegaly, hepatomegaly, and anaemia. This study evaluated the relationship between hepcidin, inflammation, iron metabolism, and hypersplenism in VL‐associated anaemia. In this cross‐sectional study, confirmed VL
Freitas AFA, Neto ASL, de Moura CMC, Silva GD, Silva MSABE, Vilges KMA, Ferreira FMAM, Costa DL, Costa CHN.   +8 more
europepmc   +2 more sources

Trend in cumulative cases and mortality rate among visceral leishmaniasis patients in Eastern Sudan: a 14-year registry, 2002–2015

International Journal of Infectious Diseases, 2016
Background: Leishmaniasis is one of the neglected infectious diseases of the world. This disease largely affects individuals of low socio-economic level, mainly in developing countries.
Gamal K. Adam, Khalid M. Ali, Yassin H. Abdella, Saeed M. Omar, Mohammed Ahmed A. Ahmed, Tajeldin M. Abdalla, AbdelAziem A. Ali   +6 more
doaj   +1 more source

Intensely clustered outbreak of visceral leishmaniasis (kala-azar) in a setting of seasonal migration in a village of Bihar, India

BMC Infectious Diseases, 2020
Background A visceral leishmaniasis outbreak was reported from a village in a low-endemic district of Bihar, India. Methods Outbreak investigation with house-to-house search and rapid test of kala-azar suspects and contacts was carried out.
Arvind Kumar, Suman Saurabh, Sarosh Jamil, Vijay Kumar   +3 more
doaj   +1 more source

Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 2021
INTRODUCTION: Malnutrition and kala-azar (or visceral leishmaniasis) are significant public health problems in different parts of the world. Immunity and susceptibility to infectious and parasitic diseases are directly linked to the host’s nutritional ...
Mísia Joyner de Sousa Dias Monteiro, Maria Nauside Pessoa da Silva, Adriana de Azevedo Paiva, Dilina do Nascimento Marreiro, Liania Alves Luzia, Gilberto Simeone Henriques, Patrícia Helen de Carvalho Rondó, Ingridi de Souza Sene, Ana Tárcila Alves de Almeida, Carlos Henrique Nery Costa, Dorcas Lamounier Costa   +10 more
doaj   +1 more source

Infection of Leishmania donovani in Phlebotomus orientalis Sand Flies at Different Microhabitats of a Kala-Azar Endemic Village in Eastern Sudan. [PDF]

Trop Med Infect Dis
Khogali A, Elnaiem DA, Díaz-Regañón R, Jibreel T, Nour BYM, Abdelrahman SH, Molina R, Jiménez M.   +7 more
europepmc   +3 more sources

Spatial and temporal variation and hotspot detection of kala-azar disease in Vaishali district (Bihar), India

BMC Infectious Diseases, 2013
Background An improved understanding in transmission variation of kala-azar is fundamental to conduct surveillance and implementing disease prevention strategies.
Bhunia Gouri Sankar, Kesari Shreekant, Chatterjee Nandini, Kumar Vijay, Das Pradeep   +4 more
doaj   +1 more source

Kidney involvement in leishmaniasis—a review

Brazilian Journal of Infectious Diseases, 2014
Leishmaniasis is an infectious disease caused by protozoa of the genus Leishmania transmitted by insects of the genus Lutzomyia sp. or Phlebotomus sp.
Geraldo Bezerra da Silva Junior, Elvino José Guardão Barros, Elizabeth De Francesco Daher   +2 more
doaj   +1 more source

Role of IL-17 gene polymorphism in Indian kala-azar

Journal of Vector Borne Diseases, 2020
Background & objectives: Visceral leishmaniasis or kala-azar is a fatal protozoan disease caused by an obligate intracellular parasite, Leishmania donovani. Susceptibility, establishment of infection and severity of this disease depend upon many factors,
R Khatonier, A M Khan, P Sarmah, G U Ahmed   +3 more
doaj   +1 more source

Risk Factors for Kala-Azar in Bangladesh

Emerging Infectious Diseases, 2005
Since 1990, South Asia has experienced a resurgence of kala-azar (visceral leishmaniasis). To determine risk factors for kala-azar, we performed cross-sectional surveys over a 3-year period in a Bangladeshi community.
Caryn Bern, Allen W. Hightower, Rajib Chowdhury, Mustakim Ali, Josef Amann, Yukiko Wagatsuma, Rashidul Haque, Katie Kurkjian, Louise E. Vaz, Moarrita Begum, Tangin Akter, Catherine B. Cetre-Sossah, Indu B. Ahluwalia, Ellen Dotson, W. Evan Secor, Robert F. Breiman, James H. Maguire   +16 more
doaj   +1 more source