Results 181 to 190 of about 919,300 (207)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

5G NR TIZIMIDA KAM HARAKATCHAN QURILMALARNI ANIQLASH MEZONI VA MEASUREMENT REPORT ENERGIYA SARFINI HISOBGA OLGAN DRX QUVVAT MODELI

Ushbu maqolada 5G NR tizimida kam harakatchan IoT va RedCap qurilmalarni signal statistikasi asosida aniqlash masalasi ko‘rib chiqiladi. RSRP va SINR signallarining dispersiyasi hamda vaqt bo‘yicha gradienti qurilma harakatchanligini baholash uchun mezon sifatida tahlil qilinadi. Connected-mode DRX mexanizmining to‘
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

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Impact of auditor characteristics and Covid-19 Pandemic on KAMs reporting

Managerial Auditing Journal, 2022
Purpose This paper aims to investigate how auditors’ characteristics affect key audit matters (KAMs) in the new audit report. It also provides an understanding of the effect of the COVID-19 pandemic on different audit reporting decisions and audit quality in specific industries.
Mohamed Abdel Aziz Hegazy, Rasha El-Haddad, Noha Mahmoud Kamareldawla   +2 more
openaire   +1 more source

ANALYSIS OF REPORTING TRANSPARENCY IN FINANCIALAUDIT THROUGH KAM AND GENDER DIFFERENCES

European Financial Resilience and Regulation. EUFIRE 2023, 2023
One of the dimensions of quality reporting in financial auditing is the transparency of information presented in audit reports by financial auditors. In recent years, in order to improve transparency in financial auditing, and thus increase the quality of audit reports, regulators have established that a separate section of the audit report is reserved
MARIA GROSU, CAMELIA CĂTĂLINA MIHALCIUC, CIPRIAN APOSTOL   +2 more
openaire   +1 more source

A Report on Some New KAM Estimates

1988
In this paper we consider near-integrable Hamiltonian systems, namely, perturbations of completely integrable Hamiltonian systems. In particular, we will discuss the following example which has a direct interest in Celestial Mechanics.
CELLETTI, ALESSANDRA, Chierchia, L.
openaire   +3 more sources

Disclosure of key audit matters (KAMs) in financial reporting: evidence from an emerging economy

Journal of Accounting in Emerging Economies, 2022
PurposeThe new audit regulation for disclosure of key audit matters (KAMs) in financial reporting has been introduced in both developed and developing countries. This study investigates the influence of three distinctive sets of variables, namely industry features, firm characteristics and auditor attributes, on the extent, pattern and level of ...
Md Mustafizur Rahaman, Md Moazzem Hossain, Md. Borhan Uddin Bhuiyan   +2 more
openaire   +3 more sources

External auditor and KAMs reporting in alternative capital market of Thailand

Meditari Accountancy Research, 2021
Purpose This study aims to investigate the extent, level and pattern of key audit matters (KAMs) reporting by companies listed in the market for alternative investment (MAI) in Thailand, and to test for a relationship between the external auditors and KAMs reporting.
openaire   +1 more source