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Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

open access: yesAdvanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang   +23 more
wiley   +1 more source
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A Dvoretzky–Kiefer–Wolfowitz type inequality for the Kaplan–Meier estimator

Annales de l'Institut Henri Poincare (B) Probability and Statistics, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bitouzé, D., Laurent, B., Massart, P.
openaire   +1 more source

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