Results 141 to 150 of about 510,488 (255)

Treatment approaches for non-metastatic small cell bladder cancer: a meta-analysis of reconstructed Kaplan-Meier curves. [PDF]

Clin Transl Radiat Oncol
Mose L, Maitre P, Eberz P, Zilli T, Mohamad O, Murthy V, Fankhauser CD, Kiss B, Roth B, Aebersold DM, Vogl U, Shelan M.   +11 more
europepmc   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Mortality after urgent versus elective transcatheter aortic valve replacement: a systematic review and meta-analysis using reconstructed individual patient data from Kaplan-Meier curves. [PDF]

BMC Cardiovasc Disord
Babaei M, Fallahtafti P, Mohammadi NSH, Azarboo A, Habibzadeh A, Azizpour A, Rashedi S, Mattumpuram J, Mohsen A, Hosseini Z, Soleimani H, Kolte D.   +11 more
europepmc   +1 more source

Displaying survival of patient groups defined by covariate paths: Extensions of the Kaplan-Meier estimator. [PDF]

Stat Med, 2021
Jay M, Betensky RA.
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Use of Kaplan-Meier and Cox regressions in the distribution of length of stay in animal shelters for pre-specified calendar periods: Definition, computation, and examples of dog length of stay in orange county California. [PDF]

PLoS One
Mavrovouniotis ML.
europepmc   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Prognostic and predictive microRNA panels for heart failure patients with reduced or preserved ejection fraction: a meta-analysis of Kaplan-Meier-based individual patient data. [PDF]

BMC Med
Parvan R, Becker V, Hosseinpour M, Moradi Y, Louch WE, Cataliotti A, Devaux Y, Frisk M, Silva GJJ, AtheroNET COST Action CA21153.   +9 more
europepmc   +1 more source

Using extracted data from Kaplan-Meier curves to compare COVID-19 vaccine efficacy

, 2023
Tansawet A, Numthavaj P, Oranratnachai S, Filbertine G, Kiertiburanakul S, McKay GJ, Attia J, Thakkinstian A.   +7 more
europepmc   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source