Results 171 to 180 of about 877,857 (301)

Kaplan-Meier Analysis Inconsistencies in a TriNetX Study of Intervention Rates for Rezum vs. Urolift. [PDF]

Int J Urol
Wang J.
europepmc   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Visualizing Time-Varying Effect in Survival Analysis: 5 Complementary Plots to Kaplan-Meier Curve. [PDF]

Oxid Med Cell Longev, 2022
Huang Q, Tian C.
europepmc   +1 more source

Multitask Deep Learning Model for Predicting Lymph Node Metastasis and Disease‐Free Survival From Cytology Images in Bladder Cancer: A Multicenter Study With Pan‐Cytology Validation

Advanced Science, EarlyView.
Through self‐supervised pretraining and supervised fine‐tuning on large‐scale cytology image datasets, CytoNet predicts lymph node metastasis and survival. Across independent cohorts, this multitask framework demonstrates robust performance, improves risk stratification beyond radiological assessment, and provides interpretable evidence to support ...
Guibin Hong, Fan Jiang, Ye Xie, Xiaowei Huang, Runnan Shen, Yun Wang, Mengyi Zhu, Haoxuan Wang, Hongkun Yang, Yanxiao Nie, Zhen Lin, Rui Chen, Nengtai Ouyang, Tianxin Lin, Shaoxu Wu   +14 more
wiley   +1 more source

Survival in unresectable hepatocellular carcinoma: Comparison of four treatments based on patients reconstructed from Kaplan-Meier curves of randomized trials. [PDF]

World J Gastrointest Pharmacol Ther
Damuzzo V, Vecchia S, Gasperoni L, Del Bono L, Ossato A, Orlandi E, Messori A.   +6 more
europepmc   +1 more source

A Comparison of Statistical Analysis Between "Real" Patients Reported in Kaplan-Meier Curves and "Reconstructed" Patients Estimated Through the IPDfromKM Method: Analysis of Eight Trials Evaluating Catheter Ablation of Ventricular Tachycardia. [PDF]

Cureus, 2023
Messori A, Fadda V, Romeo MR, Veneziano S, Trippoli S.   +4 more
europepmc   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Rethinking survival visualisation: moving beyond Kaplan-Meier curves and hazard ratios in urology. [PDF]

Transl Androl Urol
Yajima S, Yoshida S, Masuda H, Fujii Y.
europepmc   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Will the Knee Outlive the Patient? Kaplan-Meier Systematically Overstates the Lifetime Risk of Revision After Total Knee Arthroplasty. [PDF]

JB JS Open Access
Hoskins W, Gusho CA, Rosser K.
europepmc   +1 more source