Results 51 to 60 of about 730,949 (275)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A Comparison between Kaplan-Meier and Weighted Kaplan-Meier Methods of Five-Year Survival Estimation of Patients with Gastric Cancer

Acta Medica Iranica, 2014
The 5-year survival rate is a good prognostic indicator for patients with Gastric cancer that is usually estimated based on Kaplan-Meier. In situations where censored observations are too many, this method produces biased estimations. This study aimed to
Ali Zare, Mahmood Mahmoodi, Kazem Mohammad, Hojjat Zeraati, Mostafa Hosseini, Kourosh Holakouie Naieni   +5 more
doaj  

Extrapolating empirical long-term survival data: the impact of updated follow-up data and parametric extrapolation methods on survival estimates in multiple myeloma

BMC Medical Research Methodology, 2023
Background In economic evaluations, survival is often extrapolated to smooth out the Kaplan-Meier estimate and because the available data (e.g., from randomized controlled trials) are often right censored.
LJ Bakker, FW Thielen, WK Redekop, CA Uyl-de Groot, HM Blommestein   +4 more
doaj   +1 more source

Understanding survival analysis: Kaplan-Meier estimate

International Journal of Ayurveda Research, 2010
Kaplan-Meier estimate is one of the best options to be used to measure the fraction of subjects living for a certain amount of time after treatment. In clinical trials or community trials, the effect of an intervention is assessed by measuring the number of subjects survived or saved after that intervention over a period of time. The time starting from
Goel, Manish Kumar, Khanna, Pardeep, Kishore, Jugal   +2 more
openaire   +3 more sources

Feasibility and Efficacy of Definitive Radiotherapy with 66 Gy and Concurrent Carboplatin-Paclitaxel Chemotherapy for Stage III Non-Small Cell Lung Cancer. [PDF]

, 2017
Purpose/Objectives : This study was conducted to assess the feasibility and efficacy of definitive radiotherapy (RT) with a total dose of 66 Gy and concurrent carboplatin-paclitaxel chemotherapy for patients (pts) with stage Ⅲ non-small celllung cancer ...
Asakawa, Isao, Hasegawa, Masatoshi, Hontsu, Shigeto, Inoue, Kazuya, Kimura, Hiroshi, Miura, Sachiko, Tamamoto, Tetsuro, Yoshimine, Tadashi   +7 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Meteorological and Agricultural Drought Risk Assessment via Kaplan–Meier Survivability Estimator

Agriculture
Dry periods and drought are inherent natural occurrences. However, due to the increasing pressures of global warming and climate change, these events have become more frequent and severe on a global scale.
Cem Polat Cetinkaya, Mert Can Gunacti
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Estimador de Kaplan-Meier na avaliação do tempo de conclusão do Profmat/UFSJ

REMAT, 2019
A presença de dados incompletos ou censuras no conjunto de dados requer técnicas estatísticas especializadas para acomodar a informação contida nessas observações, tais como a Análise de Sobrevivência.
Roberta Cristina Ferreira Arvelos, Carla Regina Guimarães Brighenti   +1 more
doaj   +1 more source

A nonparametric model-based estimator for the cumulative distribution function of a right censored variable in a finite population [PDF]

, 2014
In survey analysis, the estimation of the cumulative distribution function (cdf) is of great interest: it allows for instance to derive quantiles estimators or other non linear parameters derived from the cdf.
Casanova, Sandrine, Leconte, Eve
core   +5 more sources