Results 51 to 60 of about 510,488 (255)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Acta Medica Iranica, 2014 The 5-year survival rate is a good prognostic indicator for patients with Gastric cancer that is usually estimated based on Kaplan-Meier. In situations where censored observations are too many, this method produces biased estimations. This study aimed to
Ali Zare +5 more
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Meteorological and Agricultural Drought Risk Assessment via Kaplan–Meier Survivability Estimator
AgricultureDry periods and drought are inherent natural occurrences. However, due to the increasing pressures of global warming and climate change, these events have become more frequent and severe on a global scale.
Cem Polat Cetinkaya, Mert Can Gunacti
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundBladder cancer lacks useful and robust prognostic markers to stratify patients at risk. Our study is to identify a robust prognostic marker for bladder cancer.MethodsThe transcriptome and clinical data of bladder cancer were downloaded from ...
Jiaxing Lin +6 more
doaj +1 more source
Comparing Kaplan‐Meier curves with the probability of agreement
Statistics in Medicine, 2020 The probability of agreement has been used as an effective strategy for quantifying the similarity between the reliability of two populations. By contrast to hypothesis testing approaches based on P‐values, the probability of agreement provides a more realistic assessment of similarity by emphasizing practically important differences.
Nathaniel T. Stevens, Lu Lu
openaire +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Survival and Factors Affecting it in Lung Cancer Patients Referred to Imam Khomeini Clinic in Hamadan Province [PDF]
Disease and Diagnosis, 2019 Background: Lung cancer is one of the most common cancers and the leading cause of death due to cancer in the world. It has the highest mortality rate compared to breast, prostate, and other cancers.
Fatemeh Gohari-Ensaf +3 more
doaj +1 more source