Results 41 to 50 of about 18,301 (299)

Robust bias estimation for Kaplan–Meier survival estimator with jackknifing [PDF]

Journal of Statistical Theory and Practice, 2015
17 pages, 3 figures, 5 tables. CRiSM working paper, Paper No.
Khan, Md. Hasinur Rahaman, Shaw, J. Ewart H.   +1 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Bandwidth Selection Problem for Nonparametric Regression Model with Right-Censored Data [PDF]

Revista Română de Statistică, 2017
In this paper, the proposed estimator for the unknown nonparametric regression function is a Nadarya-Watson (Nadarya, 1964; Watson, 1964) type kernel estimator. In this estimation procedure, the censored observations are replaced by synthetic data points
Dursun AYDIN, Ersin YILMAZ
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The importance of selecting Bayesian nonparametric survival models: application to the estimation of unemployment durations

المجلة الدولية للأداء الاقتصادي, 2023
The Kaplan-Meier and Fleming-Harrington estimator in the frequentist approach are functional methods. We compare in this article the different Bayesian structures of the Kaplan-Meier and Fleming-Harrington estimators through the information deviance ...
Ahmed HAMIMES
doaj  

Semiparametric linear regression with censored data and stochastic regressors [PDF]

, 1994
We propose three new estimation procedures in the linear regression model with randomly-right censored data when the distribution function of the error term is unspecified, regressors are stochastic and the distribution function of the censoring variable
Mora, Juan
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Methods for Improving the Variance Estimator of the Kaplan–Meier Survival Function, When There Is No, Moderate and Heavy Censoring-Applied in Oncological Datasets

Frontiers in Public Health, 2022
In case of heavy and even moderate censoring, a common problem with the Greenwood and Peto variance estimators of the Kaplan–Meier survival function is that they can underestimate the true variance in the left and right tails of the survival distribution.
Habib Nawaz Khan, Qamruz Zaman, Fatima Azmi, Gulap Shahzada, Mihajlo Jakovljevic, Mihajlo Jakovljevic, Mihajlo Jakovljevic   +6 more
doaj   +1 more source

Bandwidth choice for the smooth Kaplan–Meier estimator when the censoring variable can be discontinuous

, 2022
In this paper a new cross-validation method (CVN) for selecting the bandwidth of the smooth Kaplan-Meier estimator is introduced. Its performance is compared to that of the usual cross validation by simulations.
Youndjé, Élie
core   +1 more source