Results 21 to 30 of about 46 (42)

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

A 37‐Year Retrospective Analysis Reveals a High Rate of Cutaneous Angiosarcoma of the Scalp in Okinawa, Japan

Cancer Science, Volume 116, Issue 4, Page 1059-1067, April 2025.
A 37‐year retrospective analysis has revealed an exceptionally high rate of angiosarcoma of the scalp in Okinawa, Japan. This study represents the first identification of Okinawa as a hotspot for this rare cancer, the epidemiology of which has been insufficiently studied.
Aoi Ohira, Daisuke Utsumi, Ryoko Awazawa, Nobutake Yagi, Tsuyoshi Awazawa, Sayaka Yamaguchi, Teruki Yanagi, Kenzo Takahashi   +7 more
wiley   +1 more source

The S‐Phase Arrest of Host Cells Caused by an Alpha‐Herpesvirus Genome Replication Facilitates Viral Recruitment of RNA Polymerase II to Transcribe Viral Genes

Cell Proliferation, EarlyView.
Viral infection arrests host cells in the S phase, which promotes vDNA synthesis and vRC formation, further facilitating viral recruitment of RNA Pol II to preferentially transcribe viral genes. ABSTRACT Herpesviruses rely on host RNA polymerae II (RNA Pol II) for their mRNA transcription, yet the mechanisms of which has been poorly defined, while ...
Qiqi Yang, Ying Wu, Mingshu Wang, Shun Chen, Renyong Jia, Qiao Yang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng   +16 more
wiley   +1 more source

A Cutaneous Vascular Neoplasm With an EWSR1‐NFATC2 Translocation—Contributing to the Spectrum of Vascular Lesions Characterized by NFATC‐Related Fusions

Journal of Cutaneous Pathology, Volume 52, Issue 6, Page 410-413, June 2025.
ABSTRACT Recently, a distinct subgroup of vascular neoplasms has been identified, characterized by NFATC‐related fusions. Although existing literature is limited, these lesions histologically show a variable appearance with a tendency for local recurrence but not distant spread.
B. Schurink, A. M. van Huizen, C. D. Savci‐Heijink, E.‐J. Kooi   +3 more
wiley   +1 more source

Is Kaposi sarcoma a novel comorbidity of cutaneous lymphoma? A systematic review of the literature

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 4, Page 467-477, April 2025.
Summary Background and Objectives Patients with cutaneous lymphomas (CL) are at an increased risk of developing secondary malignancies. This study aimed to assess the frequency of association between CL and Kaposi sarcoma (KS) and to identify factors that may promote the co‐occurrence of these two diseases.
Rose K. C. Moritz, Julia Huynh, Gabriela Poch, Robert Sabat, Max Schlaak, Gabor Dobos   +5 more
wiley   +1 more source

Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review

European Journal of Clinical Investigation, EarlyView.
Abstract Background Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.
Janaina B. Medina, Fábio França Vieira e Silva, Rafael Antônio Velôso Caixeta, Bruna de Oliveira Rech, Alba Perez‐Jardón, María Elena Padín‐Iruegas, Mario Pérez‐Sayáns, Paulo Henrique Braz‐Silva, Karem L. Ortega   +8 more
wiley   +1 more source

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source

A programmatic assessment of dolutegravir adverse events and discontinuations in Uganda

HIV Medicine, Volume 26, Issue 4, Page 592-605, April 2025.
Abstract Introduction Dolutegravir is now extensively used in sub‐Saharan Africa as a preferred component of antiretroviral therapy (ART). There is a paucity of large studies using routinely collected data from African people living with HIV on dolutegravir‐based regimens to inform HIV programmes.
Eva Agnes Laker Odongpiny, Melanie Nicol, Elizabeth Katana, Joseph Owori, Allan Buzibye, Kay Sedan, Mike Kesby, Matthew Holden, Noela Owarwo, David Meya, Barbara Castelnuovo, Derek J. Sloan, Christine Sekaggya   +12 more
wiley   +1 more source

Real‐world outcomes of vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome at a tertiary referral centre

British Journal of Haematology, EarlyView.
Lucia Lee, Eric J. Zhao, Robert Schmidt, Alym Abdulla, Gayatri Sreenivasan, Kimberley Ambler, Megan Hiltz, Lynda Foltz, Vicki Chan, Alexandra Legge, Maggie Yuen, Lauren Lee, Paul Yenson, Thomas J. Nevill, Luke Y. C. Chen, Ryan J. Stubbins   +15 more
wiley   +1 more source

Cone Beam CT Sialography for the Assessment of Submandibular Gland Structure in Diabetes Mellitus

Oral Diseases, EarlyView.
ABSTRACT Objective To examine the anatomical and morphological structure and potential pathological conditions of the submandibular gland by performing Cone Beam Computed Tomography (CBCT) sialography in patients with diabetes mellitus. Study Design The submandibular salivary glands of 25 diabetic and 25 healthy volunteers were examined by CBCT ...
Muhammed Akif Sümbüllü, Kübra Başaran Aslan, Fatma Çağlayan   +2 more
wiley   +1 more source