Results 41 to 50 of about 29,185 (239)

Outcomes of patients with Kaposi's sarcoma who start antiretroviral therapy under routine programme conditions in Malawi. [PDF]

, 2008
AIDS-associated Kaposi's sarcoma (KS) is the most common AIDS-related malignancy in sub-Saharan Africa, with a generally unfavourable prognosis. We report on six-month and 12-month cohort treatment outcomes of human immunodeficiency virus (HIV)-positive ...
Anthony D Harries, Edwin Libamba, Erik J Schouten, Eustice Mhango, Joseph Kwong-Leung Yu, Libamba E, Libamba E, Lynen L, Margaret Fitzgerald, Mindy Hochgesang, Olesi Pasulani, Ralf Weigel, Simon D Makombe, World Health Organization, UNAIDS., World Health Organization.   +14 more
core   +2 more sources

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Stakeholder perspectives on barriers and facilitators to hypertension control in urban Haiti: a qualitative study to inform a community-based hypertension management intervention

BMC Public Health
Background Uncontrolled hypertension is the leading modifiable risk factor for cardiovascular disease mortality and remains high in low-middle income countries like Haiti.
Reichling St Sauveur, Rodney Sufra, Marie Christine Jean Pierre, Joseph Inddy, Mirline Jean, Nour Mourra, Radhika Sundararajan, Margaret L. McNairy, Jean W. Pape, Vanessa Rouzier, Jessy Devieux, Lily D. Yan   +11 more
doaj   +1 more source

Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections. [PDF]

, 2018
The CRISPR/Cas9 system has been applied in the genome editing and disruption of latent infections for herpesviruses such as the herpes simplex virus, Epstein⁻Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus.
Chen, Yuan-Chuan, Liu, Fenyong, Sheng, Jingxue, Trang, Phong   +3 more
core   +2 more sources

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Capturing metabolic syndrome in low-resource settings: a case study in urban Haiti

Frontiers in Endocrinology
IntroductionLocal epidemiologic data on risk factors for heart disease are needed in low-income settings to guide targeted interventions for prevention and treatment.
Nour Mourra, Vanessa Rouzier, Vanessa Rouzier, Rodney Sufra, Reichling St Sauveur, Jodany Bernadin, Joseph Inddy, Alexandra Apollon, Rehana Rasul, Anju Ogyu, Lily D. Yan, Lily D. Yan, Jean W. Pape, Margaret McNairy, Margaret McNairy   +14 more
doaj   +1 more source

Patient‐ and caregiver‐reported barriers to radiotherapy for cancer in sub‐Saharan Africa—A survey of population‐based registries

International Journal of Cancer, EarlyView.
What's New? Low‐ and middle‐income countries have over 70% of the global cancer burden but 10% of the world's radiotherapy capacities. This population‐based multi‐country study explores the barriers to access experienced by cancer patients in sub‐Saharan Africa.
Eric Sven Kroeber, Tamara König, Ole Stöter, Biying Liu, Phoebe Mary Amulen, Margaret Borok, Gladys Chesumbai, Eric Chokunonga, Ima‐Obong Ekanem, Mahine Ivanga, Bakarou Kamaté, William Muller, Abidemi Omonisi, Jean‐Félix Peko, Mathewos Assefa, Furaha Serventi, Markus Wallwiener, Mazvita Muchengeti, Pablo Sandro Carvalho Santos, Donald Maxwell Parkin, Eva Johanna Kantelhardt, Nikolaus Christian Simon Mezger   +21 more
wiley   +1 more source

Left ventricular hypertrophy among adults in a population-based cohort in Haiti

Scientific Reports
Left ventricular hypertrophy (LVH) is one of the strongest predictors of cardiovascular disease (CVD) and mortality; yet the means to diagnose LVH in resource-constrained settings remain limited.
Anju Ogyu, Vanessa Rouzier, Rodney Sufra, Reichling St Sauveur, Marie Christine Jean-Pierre, Joanna Q. Lin, Nour Mourra, Fabiola Preval, Mirline Jean, Richard B. Devereux, Altaf Pirmohamed, Parag Goyal, Lisa de las Fuentes, Victor G. Dávila-Román, Wheytnie Alexandre, Robert N. Peck, Marie-Marcelle Deschamps, Jean W. Pape, Margaret L. McNairy, Lily D. Yan   +19 more
doaj   +1 more source

Rainbow Kaposi's Sarcoma-Associated Herpesvirus Revealed Heterogenic Replication with Dynamic Gene Expression. [PDF]

, 2020
Molecular mechanisms of Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation have been studied primarily by measuring the total or average activity of an infected cell population, which often consists of a mixture of both nonresponding and ...
Campbell, Mel, Chuang, Frank, Guevara-Plunkett, Sara, Izumiya, Chie, Izumiya, Yoshihiro, Kumar, Ashish, Luxardi, Guillaume, Lyu, Yuanzhi, Nakajima, Ken-Ichi, Soulika, Athena, Wang, Kang-Hsin   +10 more
core  

Experiences With Surgical Treatment of Chronic Lower Limb Ulcers at a Tertiary Hospital in Northwestern Tanzania: A Prospective Review of 300 Cases. [PDF]

, 2012
Chronic lower limb ulcers constitute a major public health problem of great important all over the world and contribute significantly to high morbidity and long-term disabilities. There is paucity of information regarding chronic lower limb ulcers in our
Chalya, Phillipo L, Gilyoma, Japhet M, Kidenya, Benson R, Mbunda, Fidelis, McHembe, Mabula D, Mshana, Stephen E, Rambau, Peter   +6 more
core   +3 more sources