Results 41 to 50 of about 27,477 (196)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Association between charcoal cooking fuel and cardiovascular disease prevalence in Haiti: a cross-sectional analysis

Environmental Health
Background There is little evidence on the association between cooking with polluting fuels, particularly charcoal, and heart disease from low- and middle-income countries, which have the highest burdens of polluting fuels and cardiovascular disease (CVD)
Lily D. Yan, Rodney Sufra, Reichling St Sauveur, Kelly Celestin, Vanessa Rouzier, Alexandra Apollon, Guyrlaine Forestal, Suzanne Edwidge Marcelin, Sarine Auguste, Josue Pierre, Erline Hilaire, James-Lee Fénélus, Anju Ogyu, Catherine Bennett, Rehana Rasul, Lindsay J. Underhill, Mark D. Huffman, Victor G. Davila-Roman, Jennifer L. Peel, Gene F. Kwan, Marie Marcelle Deschamps, Jean W. Pape, Margaret L. McNairy   +22 more
doaj   +1 more source

Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]

, 2013
The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Brulois, Kevin, Izumiya, Yoshihiro, Jung, Jae U, Kung, Hsing-Jien, Lee, Hye-Ra, Tepper, Clifford, Toth, Zsolt   +6 more
core   +3 more sources

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Stakeholder perspectives on barriers and facilitators to hypertension control in urban Haiti: a qualitative study to inform a community-based hypertension management intervention

BMC Public Health
Background Uncontrolled hypertension is the leading modifiable risk factor for cardiovascular disease mortality and remains high in low-middle income countries like Haiti.
Reichling St Sauveur, Rodney Sufra, Marie Christine Jean Pierre, Joseph Inddy, Mirline Jean, Nour Mourra, Radhika Sundararajan, Margaret L. McNairy, Jean W. Pape, Vanessa Rouzier, Jessy Devieux, Lily D. Yan   +11 more
doaj   +1 more source

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Capturing metabolic syndrome in low-resource settings: a case study in urban Haiti

Frontiers in Endocrinology
IntroductionLocal epidemiologic data on risk factors for heart disease are needed in low-income settings to guide targeted interventions for prevention and treatment.
Nour Mourra, Vanessa Rouzier, Vanessa Rouzier, Rodney Sufra, Reichling St Sauveur, Jodany Bernadin, Joseph Inddy, Alexandra Apollon, Rehana Rasul, Anju Ogyu, Lily D. Yan, Lily D. Yan, Jean W. Pape, Margaret McNairy, Margaret McNairy   +14 more
doaj   +1 more source

Incidence of WHO stage 3 and 4 conditions following initiation of Anti-Retroviral Therapy in resource limited settings [PDF]

, 2012
To determine the incidence of WHO clinical stage 3 and 4 conditions during early anti-retroviral therapy (ART) in resource limited settings (RLS)
A d’Arminio Monforte, A Miranda, Andrea J. Curtis, AS Walker, B Castelnuovo, B Ledergerber, Catherine S. Marshall, CE Gonzalez, Daniel P. O’Brien, DJ Sloan, DR Hoover, Esther C. Casas, J Abadi, J Mermin, Jane Greig, JE Golub, JE Kaplan, JF Etard, Julian H. Elliot, K Buchacz, Leslie Shanks, M-L Newell, Marcio Silveria Da Fonseca, NJ Ives, Philipp Du Cros, R Zachariah, SD Lawn, Sten H. Vermund, Tim Spelman, VO Kasprowicz, W Manosuthi   +30 more
core   +3 more sources

Patient‐ and caregiver‐reported barriers to radiotherapy for cancer in sub‐Saharan Africa—A survey of population‐based registries

International Journal of Cancer, EarlyView.
What's New? Low‐ and middle‐income countries have over 70% of the global cancer burden but 10% of the world's radiotherapy capacities. This population‐based multi‐country study explores the barriers to access experienced by cancer patients in sub‐Saharan Africa.
Eric Sven Kroeber, Tamara König, Ole Stöter, Biying Liu, Phoebe Mary Amulen, Margaret Borok, Gladys Chesumbai, Eric Chokunonga, Ima‐Obong Ekanem, Mahine Ivanga, Bakarou Kamaté, William Muller, Abidemi Omonisi, Jean‐Félix Peko, Mathewos Assefa, Furaha Serventi, Markus Wallwiener, Mazvita Muchengeti, Pablo Sandro Carvalho Santos, Donald Maxwell Parkin, Eva Johanna Kantelhardt, Nikolaus Christian Simon Mezger   +21 more
wiley   +1 more source

Left ventricular hypertrophy among adults in a population-based cohort in Haiti

Scientific Reports
Left ventricular hypertrophy (LVH) is one of the strongest predictors of cardiovascular disease (CVD) and mortality; yet the means to diagnose LVH in resource-constrained settings remain limited.
Anju Ogyu, Vanessa Rouzier, Rodney Sufra, Reichling St Sauveur, Marie Christine Jean-Pierre, Joanna Q. Lin, Nour Mourra, Fabiola Preval, Mirline Jean, Richard B. Devereux, Altaf Pirmohamed, Parag Goyal, Lisa de las Fuentes, Victor G. Dávila-Román, Wheytnie Alexandre, Robert N. Peck, Marie-Marcelle Deschamps, Jean W. Pape, Margaret L. McNairy, Lily D. Yan   +19 more
doaj   +1 more source