Results 71 to 80 of about 218,311 (307)

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Exploring the Hemoglobin T to R2 Path Using Gaussian Elastic Network Correlation Map Distance

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are dynamic and undergo conformational changes. These changes may affect the motions executed by different regions of the proteins and are reflected in the motion correlation map. A method to accurately measure these changes is presented and exemplified on a set of tetrameric Hemoglobin structures.
Yuval Valenci, Dror Tobi
wiley   +1 more source

Speculations on the clinical significance of asymptomatic viral infections [PDF]

, 2016
A detailed understanding of asymptomatic chronic viral infections is critical to analyse their pathogenesis, assess the severity and burden of disease and, where required, optimize public health control measures.
Gentile, Giuseppe, Micozzi, Alessandra
core   +1 more source

Robustness of a convolutional neural network trained on dermoscopic images and challenged with close‐up images

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Deep learning‐convolutional neural networks (DL‐CNNs) have demonstrated high diagnostic accuracy within the domain of dermoscopy. However, many clinical settings lack dermoscopic devices, requiring reliance on close‐up images. This study evaluates the robustness of a DL‐CNN trained on dermoscopic images when challenged
Anastasia Sophie Vollmer, Julia Katharina Winkler, Katharina Susanne Kommoss, Wilhelm Stolz, Albert Rosenberger, Alexander Enk, Holger Andreas Haenssle   +6 more
wiley   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, EarlyView.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

Bronchopulmonary Kaposi's sarcoma

Respiratory Medicine Case Reports, 2015
Kaposi's sarcoma (KS) is a highly vascular tumour, which was first described by the Hungarian dermatologist Moritz Kaposi Kohn before the discovery of the human immunodeficiency virus (HIV). Historically, KS has been linked to immunosuppression or to elderly male patients, especially in relation to diffuse cutaneous KS.
Bashar, Nada, Innes, Nicholas, Orrell, Julian   +2 more
openaire   +3 more sources

Limited asymptomatic carriage of Pneumocystis jiroveci in human immunodeficiency virus-infected patients [PDF]

, 2003
Forty-seven bronchoalveolar lavage fluid samples from 16 human immunodeficiency virus (HIV)-infected patients were used to test the latency model of Pneumocystis infection in the human host.
Ambrose, HE, Denis, CM, Lindley, AR, Miller, RF, Wakefield, AE   +4 more
core  

Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases

The FEBS Journal, EarlyView.
Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu, Noemi Nagy, Carlos Mario Ayala‐Torres, Maria G. Masucci   +3 more
wiley   +1 more source

Sarcoma de Kaposi ocular. Presentación de un caso.

Gaceta Médica Espirituana, 2012
Fundamento: el sarcoma de Kaposi es una enfermedad tumoral descrita por primera vez por el médico húngaro Morita Kaposi en 1872 y puede presentarse con marcada frecuencia en pacientes seropositivos como enfermedad marcadora de sida. Presentación de caso:
Axel López Valdés, Vivian María Couce Herrera, Erians Valdés Pérez, Roxana María Almanza Alarcón, Edelby Escobar Carmona   +4 more
doaj  

SARCOMA DE KAPOSI ANAPLÁSICO MIMETIZANDO ANGIOSSARCOMA

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2014
Introdução: O angiossarcoma é o tumor vascular mais frequente no contexto de linfedema crónico, entidade conhecida como síndrome de Stewart-Treves. Contudo, é sabido que o sarcoma de Kaposi se acompanha frequentemente de linfedema (por vezes antecedendo ...
Vera Teixeira, José Carlos Cardoso, Miguel Pinto Gouveia, Angelina Mariano, Óscar Tellechea, Américo Figueiredo   +5 more
doaj   +1 more source