Results 71 to 80 of about 3,079 (142)

RAS Pathway Mutations and Therapeutics in Vascular Anomalies

Pediatric Blood &Cancer, Volume 72, Issue 5, May 2025.
ABSTRACT Vascular anomalies (VAs) are a diverse group of vascular tumors and vascular malformations (VMs). VMs are characterized by abnormal vessel development, overgrowth, and dysfunction. Coagulopathy, edema, and effusions can cause severe morbidity and mortality in children and adults with these diseases. Germline or somatic mutations in the RAS/RAF/
Sara Alharbi, Svatava Merkle, Adrienne M. Hammill, Andrew M. Waters, Timothy D. Le Cras   +4 more
wiley   +1 more source

Kaposiform hemangioendothelioma arising from the internal auditory canal

, 2006
Kaposiform hemangioendothelioma is a rare vascular tumor and locally aggressive endothelial-derived spindle cell neoplasm, which occurs almost exclusively in infants and adolescents.
Kwon, B J, Kang, H S, Chang, J M, Han, M H, Chang, K H   +4 more
core  

Kaposiform hemangioendothelioma: Five patients with cutaneous lesion and long follow-up

, 2001
Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor of the skin, deep soft tissue, and bone in children, characterized by infiltrating nodules and sheets of spindle cells, and unmistakable resemblance to Kaposi's sarcoma.
Kumta, SM, MacMoune Lai, F, Choi, PCL, Leung, PC, Allen, PW, Lam, WY, Cheung, ANY, To, KF, Yuen, PPM   +8 more
core   +1 more source

Kaposiform hemangioendothelioma: current knowledge and future perspectives

Orphanet Journal of Rare Diseases, 2020
Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm with high morbidity and mortality. The initiating mechanism during the pathogenesis of KHE has yet to be discovered.
Yi Ji, Siyuan Chen, Kaiying Yang, Chunchao Xia, Li Li   +4 more
doaj   +1 more source

Intracranial kaposiform hemangioendothelioma: proposal of a new malignant variant

, 2009
Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy and early childhood that occurs mainly in soft tissue and the retroperitoneum.
Cho, Won-Sang, Park, Sung-Hye, Kim, Seung-Ki, Cho, Byung-Kyu   +3 more
core   +1 more source

Intra-abdominal kaposiform hemangioendothelioma and the benefits of laparoscopic surveillance.

, 2012
We report a case of a neonate presenting with the rare vascular tumor, Kaposiform hemangioendothelioma. She had a lesion arising from the left ovary with multiple intraperitoneal metastases causing small bowel obstruction.
Thompson, CV, Brundler, MA, Wells, Jonathan, Arul, GS, Kearns, Pamela; id_orcid, Bowen, C   +5 more
core   +1 more source

Response to Paclitaxel in an Adult Patient with Advanced Kaposiform Hemangioendothelioma

Case Reports in Oncology, 2016
Background: Kaposiform hemangioendothelioma (KHE) is a rare neoplasm of vascular origin that typically arises from the skin or soft tissues as a solitary tumor. The optimal therapy for this disease is still unknown. We report the case of an adult patient
José Maurício Mota, Mariana Scaranti, Leonardo G. Fonseca, Diego Araújo Tolói, Veridiana Pires de Camargo, Rodrigo Ramella Munhoz, Olavo Feher, Paulo M. Hoff   +7 more
doaj   +1 more source

Congenital Kaposiform Hemangioendothelioma With Kasabach-Merritt Phenomenon Successfully Treated With Low-Dose Radiation Therapy

, 2014
Kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon is a life-threatening vasculopathy. The current mainstay treatment for KHEs is corticosteroids and chemotherapy, but these medications do not work for all patients and ...
Malhotra, Yogangi, Antaya, Richard J, Yang, Catherine S, McNamara, Joseph   +3 more
core   +1 more source

Congenital hemangiomas with transient neonatal thrombocytopenia: case reports and review of the literature

Frontiers in Pediatrics
Congenital hemangioma with thrombocytopenia is rare and is often mistaken for Kasabach-Merritt phenomenon seen in kaposiform hemangioendothelioma.
Yuan-yang Zheng, Jiajie Lv, Xiaoxi Lin, Chen Hua   +3 more
doaj   +1 more source

Pancreatic Kaposiform Hemangioendothelioma Not Responding to Sirolimus

European Journal of Pediatric Surgery Reports, 2017
Background Kaposiform hemangioendothelioma (KHE) is a vascular tumor frequently associated with Kasabach–Merritt phenomenon (KMP), characterized by severe thrombocytopenia and consumptive coagulopathy. Visceral involvement in KHE is rare.
Paloma Junco Triana, Mariela Dore, Vanesa Cerezo Nuñez, Javier Gomez Jimenez, Miriam Ferrero Miguel, Mercedes González Díaz, Joan Novo Ricardo, Ane Andres, Manuel Lopez Santamaria, Juan Carlos Lopez-Gutierrez   +9 more
doaj   +1 more source