Results 191 to 200 of about 299,878 (261)

Inter-Rater Agreement Between a Trained Nurse and Physicians in FAST Examination of Trauma Patients: A Pilot Study in the Emergency Department. [PDF]

Healthcare (Basel)
Mpouzika M, Athinis G, Karanikola M, Parissopoulos S, Papageorgiou G, Rossis C, Giannelou E.   +6 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Accuracy of a Digital Intraoral Scanner in Recording Occlusal Contact Points in Patients with Natural Dentition Compared to 8-µm Articulating Paper: A Cross-Sectional In-Vivo Study. [PDF]

Cureus
Almahdi Altounsi T, Morad ML, Hajeer MY.
europepmc   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Evaluating medical AI models beyond predictive performance: a diabetic retinopathy screening case study

Kim H, Jonas RA, Ninomiya T, Hong R, Sitnilska V, Howaldt A, ONG AY, Grün M, Poschkamp B, Zhou Y, Ju L, Lin Y, Ruffell E, Williamson D, Huemer J, Ito K, Paul N, Morley MG, Eslami M, Tobias E, Thee EF, Choi J, Lee D, Wang Y, Panda-Jonas S, Jonas JB, Bikbov MM, Kazakbaeva GM, Nangia V, Wagner SK, Hwang S, Keane PA.   +31 more
europepmc   +1 more source

Intrathecal immunoglobulin production in the diagnosis, prognosis, and monitoring of autoimmune diseases of the central nervous system. [PDF]

J Transl Autoimmun
Renaudineau Y, Puissant-Lubrano B.
europepmc   +1 more source

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

Rapid Antimicrobial Susceptibility Testing (RAST): A Quick Guide to Bacterial Sepsis Management. [PDF]

Cureus
Dinakaran S, Bhat S, Nair S, Kandasamy R.   +3 more
europepmc   +1 more source

Physics‐Informed Neural Network‐Enabled Forward Prediction and Inverse Design of Ring Origami

Advanced Science, EarlyView.
This work presents a KRT‐PINN framework that integrates Kirchhoff rod theory with physics‐informed neural networks for the forward prediction and inverse design of ring origami consisting of closed‐loop rods. The framework predicts stable states of segmented rings with prescribed natural‐curvature profiles and determines the natural‐curvature profiles ...
Luyuan Ning, Lu Lu, Sophie Leanza, Ruike Renee Zhao   +3 more
wiley   +1 more source

Validity and Reliability Assessment of the Persian Version of a EORTC QLQ-STO22 Questionnaire for Patients With Gastric Cancer Who Underwent Total Gastrectomy. [PDF]

Health Sci Rep
Mousavi A, Sahebi L, Miratashi Yazdi SA.
europepmc   +1 more source