Results 211 to 220 of about 108,883 (296)

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Stage IIIC Bilateral Dysgerminoma in 46,XY Swyer Syndrome: Preventing Malignancy Through Early Endocrine Evaluation of Primary Amenorrhea. [PDF]

Clin Case Rep
Elendu C, Sidhu AK, Okabekwa OS, Debua AT, Ali AI.   +4 more
europepmc   +1 more source

Karyotyp [PDF]

, 2018
openaire   +1 more source

Pure erythroid leukaemia in early infancy: Diagnostic pitfalls and clinical challenges

British Journal of Haematology, EarlyView.
Riccardo De Carli, Baptiste Le Calvez, Elodie Lainey, Catherine Settegrana, Marion Strullu, Marlene Pouthier   +5 more
wiley   +1 more source

A Case of Acute Myeloid Leukemia, Myelodysplasia-Related (AML-MR) with Immunophenotypic Features Suggestive of B/Myeloid Mixed-Phenotype Acute Leukemia (MPAL), Harboring Multiple <i>KMT2A</i> Gene Amplifications. [PDF]

Int J Mol Sci
Łączak J, Szarawarska M, Dudycz D, Bieńko K, Grzyb J, Skoczylas T, Blajer-Olszewska B, Kopacz A, Markiewicz M.   +8 more
europepmc   +1 more source

Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley   +1 more source

The role of hormonal markers in predicting reproductive lifespan in girls with Turner syndrome-a retrospective study. [PDF]

J Endocr Soc
van der Coelen S, Sas T, Richter-Unruh A, Braat D, Fleischer K, Nadesapillai S, IntHout J, van der Velden J.   +7 more
europepmc   +1 more source

Differential Correlation Across Subpopulations of Single Cells in Subtypes of Acute Myeloid Leukemia. [PDF]

BioTech (Basel)
McGee RL, Reed J, Behbehani GK, Coombes KR.   +3 more
europepmc   +1 more source

Identification of Complex Chromosomal Rearrangement Involving Chromosomes 10, 18, and 19 in a Family Undergoing Prenatal Diagnosis: Case Report. [PDF]

Clin Case Rep
Zhou D, Lian W, Wang H, Huang R, Deng J, Jiao S, Zhou Q.   +6 more
europepmc   +1 more source

KRAS Mutations Predict Inferior Post‐Remission Outcomes in Newly Diagnosed Acute Myeloid Leukemia With MAPK Pathway Mutations

European Journal of Haematology, EarlyView.
ABSTRACT Somatic mutations in the MAPK signaling pathway are frequently identified at AML diagnosis; however, their impact on treatment resistance and long‐term survival remains unclear. We conducted a retrospective study of patients with newly diagnosed MAPK‐mutated AML seen at the University of Iowa Health Care.
Kensuke Takaoka, Sarah Mott, Ratdanai Yodsuwan, Sakditad Saowapa, Manasawee Tanariyakul, Chalothorn Wannaphut, Kittika Poonsombudlert   +6 more
wiley   +1 more source