Results 81 to 90 of about 142,560 (388)
Simultaneous precise editing of multiple genes in human cells
, 2019 . When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results ...
Chintalapati, M. +5 more
core +1 more source
Cold Spring Harbor Protocols, 2008 INTRODUCTIONThe majority of mouse chromosome preparations for banding are now made by air-drying and, in essence, require the production of a cell suspension as a starting point. Some samples such as blood cultures, ascitic fluids, or cells growing in suspension will already be in suspension; others, such as bone marrow, solid tumors, or cells growing ...
Kristina Vintersten +3 more
openaire +3 more sources
AGING MEDICINE, EarlyView.We generated genetically stable iPSCs from HGPS patients using a nonintegrative Sendai virus method. This approach preserves cellular integrity, enhances disease modeling, and enables accurate study of Progerin‐induced cardiovascular dysfunction. Overall, it provides a reliable platform for understanding HGPS and aging‐related disease pathology and ...
Juned Kadiwala, Rameen Shakur
wiley +1 more source
A case with Emanuel syndrome: extra derivative 22 chromosome inherited from the mother
Balkan Journal of Medical Genetics, 2015 Emanuel syndrome (ES) is a rare chromosomal disorder that is characterized by multiple congenital anomalies and developmental disabilities. Affected children are usually identified in the newborn period as the offspring of balanced (11;22) translocation ...
İkbal Atli E +4 more
doaj +1 more source
Demonstration of the Presence of the "Deleted" MIR122 Gene in HepG2 Cells [PDF]
, 2015 MicroRNA 122 (miR-122) is highly expressed in the liver where it influences diverse biological processes and pathways, including hepatitis C virus replication and metabolism of iron and cholesterol.
Fei, Y +8 more
core +1 more source
Noninvasive Prenatal Molecular Karyotyping from Maternal Plasma
PLoS ONE, 2013 Fetal DNA is present in the plasma of pregnant women. Massively parallel sequencing of maternal plasma DNA has been used to detect fetal trisomies 21, 18, 13 and selected sex chromosomal aneuploidies noninvasively.
Stephanie C. Y. Yu +10 more
semanticscholar +1 more source
Tissue‐Resident Myeloid and Histiocytic Cells in Health and Disease: Novel Emerging Concepts
American Journal of Hematology, EarlyView.ABSTRACT Although all myeloid cells are considered to derive from hematopoietic stem cells, the cells in each myeloid lineage are heterogeneous populations, and their distribution and functions vary, depending on underlying physiologic and pathologic processes, age, sex, and genetic and epigenetic signatures.
Peter Valent +27 more
wiley +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Given the dismal prognosis for patients with TP53‐mutated acute myeloid leukemia (AML), the optimal donor for those undergoing allogeneic hematopoietic cell transplantation (allo‐HCT) remains unclear. We retrospectively analyzed adult patients with TP53‐mutated AML who underwent first allo‐HCT in CR1 between 2010 and 2021.
Yuhua Ru +13 more
wiley +1 more source
9q21.13q21.31 deletion in a patient with intellectual disability severe speech delay and and dysmorphic features a newly recognized microdeletion syndrome [PDF]
, 2019 The increased use of chromosomal microarray analysis has led to the identification of new microdeletion/microduplication syndromes, enabling better genotype-phenotype correlations.
Correia, Hildeberto +6 more
core +1 more source
American Journal of Hematology, EarlyView.ABSTRACT In the registration clinical trial 301 (NCT01696084), CPX‐351 has shown to be superior to conventional 3 + 7 in secondary AML (s‐AML). However, the optimal duration of treatment, the best timing for allogeneic stem cell transplantation (allo‐HSCT), and the activity of CPX‐351 in specific s‐AML subgroups are unclear.
Fabio Guolo +56 more
wiley +1 more source