Results 41 to 50 of about 58,140 (139)
18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis
Advanced Science, EarlyView.Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen +11 morewiley +1 more sourcePreserving Open Access Journals: A Literature Review [PDF]
, 2010 This literature review addresses certain questions concerning the preservation of free, born-digital scholarly materials. It covers recent thinking on the current state of preservation efforts of born-digital materials; the range of actors involved in ...Jottkandt, Sigicore Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study [PDF]
, 2018 Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor ...Abroug, S., Alcourt, Y., Allam, H., Antonelli, M., Aubrey, A., Bachoumas, K., Bangert, K., Barthelemy, R., Bartoli, C., Baudrillart, L., Bayer, S., Beeken, T., Beeker, T., Begot, E., Beishuizen, A., Beishuizen, B., Berghe, C., Bergmann, A., Berquier, G., Besancenot, H., Blet, A., Bloos, F., Bloos, P., Bodet-Contentin, L., Boivin, A., Bongiovanni, C., Bonnet, F., Border, N., Bos-Burgmeijer, M., Bouadma, L., Bouhours, G., Bourdier, J., Bourzeix, P., Braad, A., Brick, L., Brulls, C., Buelens, I., Calvat, S., Caumon, E., Cayot, S., Chapellas, C., Chassier, C., Chenaf, S., Chousterman, B. G., Clere-Jehl, R., Colin, G., Collienne, C., Constantin, J. -M., Conte, M., Cornet, A., Cracco, C., Cupaciu, A., Cutuli, S. L., D'Arrigo, S., Daix, T., Damoisel, C., De Heer, G., De Schryver, N., Deiler, V., Deisz, R., Delabranche, X., Delmas, J., Denou, F., Dequin, P. F., Desachy, A., Deschamps, A., Deye, N., Dhif, N., Di Somma, S., Digravio, V., Dubief, E., Duchambon, A. -A., Dugernier, T., Dujardin, M. -F., Ehrmann, S., Fally, M. A., Fedou, A. -L., Feld, F., Feliot, E., Fesard, P., Fiancette, M., Fournier, M. -C., Francois, B., Freys, G., Frings, D., Fuhrmann, V., Fullekrug, B., Gaillard, T., Galy, A., Garcon, P., Garot, D., Gaudry, S., Gaugain, S., Gayat, E., Geukens, P., Geven, C., Godet, T., Gonnert, F., Gouhier, C., Goury, A., Guerin, R., Guillon, A., Guyon, M., Hartmann, O., Haucke, A., Hecketsweiler, S., Heenen, S., Hemelaar, P., Henin, P., Henker, R., Henry-Lagarrigue, M., Herafa, I., Heunks, L., Hoedemaekers, A., Hohn, A., Hollinger, A., Huberlant, V., Huot, B., Jabaudon, M., Jacob, L., Janisch, T., Jaschinski, U., Joret, A., Jouan, Y., Kehl, L., Kelly, D. S., Kerdjana, L., Kerinn, M., Kerymel, M., Kluge, S., Kohlberg, K. K., Kolanos, S., Kortgen, A., Kreuser, I., Kummerlen, C., La Combe, B., La Foucher, B., Lacherade, J. -C., Lafon, C., Laissi, M., Laleu, S., Lascarrou, J. -B., Lascarrou, J. B., Lasocki, S., Laterre, P. -F., Laterre, P. F., Launoy, A., Laurent, Y., Lebert, C., Leblanc, D., Lebreton, S., Legall, C., Legrand, M., Legras, A., Lematte, M., Leone, F. E., Lessinger, J. -M., Letrou, S., Lindau, S., Loiez, A., Louadah, B., Lucht, A., Ludes, P. O., Mabilat, C., Magalhaes, E., Mairesse, J., Malissin, I., Mancia, C., Manivet, P., Maquigneau, N., Martin-Levevre, L., Marx, G., Marx, N., Massat, S., Mebazaa, A., Megarbane, B., Meier, B., Meier-Hellmann, A., Meinig, T., Mercier, E., Messika, J., Metzger, C., Meybohm, P., Meyer, A., Meziani, F., Mourvillier, B., Muller, J., Mutlak, H., Navarin, S., Neuville, M., Nierhaus, A., Nouaille, M., Orru, M., Oueslati, H., Papendorp, S., Pascal, J., Perbet, S., Petre, H., Pezechk, J., Pichon, N., Pickkers, P., Pierre, V., Pottecher, J., Quatrocchi, D., Quattrochi, D., Rabouel, Y., Radji, S., Radjou, A., Rahmani, H., Reignier, J., Renard, S., Ricard, J. -D., Ringeis, G., Rinket, M., Robert, A., Robin, L., Rodier, N., Rolhion, C., Rommer, M., Roovers, N., Roszyk, L., Rouleau, S., Rousseau, C., Rouve, E., Roux, D., Ruimy, A., Russo, V., Salmon, C., Schedler, D., Schindler, A., Schnell, D., Schreiber, J., Schroder, D., Schuerholz, T., Schwope, K., Scigalla, P., Sebastien, L., Sensen, B., Siedler, S., Siewecke, A., Simeon-Vieules, V., Simon, T. -P., Simona, S., Singer, B., Soffker, G., Sonneville, R., Soyer, B., Struck, J., Szozot, M., Thibault, S., Thirifays, A., Thomas-Ruddel, D., Timsit, J. -F., Trine, H., Trof, R. J., Vallecoccia, M. S., Van Der Hoeven, H., Van Wezel, H., Varchetta, A., Verlhac, C., Vermeijden, J., Victori, G., Vignon, P., Vinatier, I., Vinetti, M., Voicu, S., Wetsch, W., Wichmann, D., Wittebole, X., Yehia, A., Zacharowski, K. D., Zanquila, M., Zapatero, D. C., Zinzonni, V. E., Zoccoli, G. +274 morecore +1 more sourcePrediction of Structural Stability of Layered Oxide Cathode Materials: Combination of Machine Learning and Ab Initio Thermodynamics
Advanced Energy Materials, EarlyView.In this work, we developed a phase‐stability predictor by combining machine learning and ab initio thermodynamics approaches, and identified the key factors determining the favorable phase for a given composition. Specifically, a lower TM ionic potential, higher Na content, and higher mixing entropy favor the O3 phase.Liang‐Ting Wu, Milica Zdravković, Dijana Milosavljević, Konstantin Köster, Olivier Guillon, Jyh‐Chiang Jiang, Payam Kaghazchi +6 morewiley +1 more sourceIslands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes [PDF]
, 2016 Human cytomegalovirus (HCMV) infects most of the population worldwide, persisting throughout the host's life in a latent state with periodic episodes of reactivation.Atkinson, Claire, Balloux, Francois, Breuer, Judith, Brown, Amanda C., Brown, Julianne R., Christiansen, Mette T., Clark, Duncan A., Depledge, Daniel P., Einer-Jensen, Katja, Griffiths, Paul D., Holdstock, Jolyon, Lassalle, Florent, Milne, Richard S.B., Reeves, Matthew B., Schutten, Martin, Tutill, Helena J., van Loenen, Freek B., Verjans, Georges M.G.M., Williams, Rachel J. +18 morecore +1 more sourceUncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background
Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...Do‐Yeon Cho, Alexis E. McFeely, Daniel Skinner, Shaoyan Zhang, Justin Hedvat, Weslee Ping‐ay, Daniel M. Beswick, Justin H. Turner, Bradford A. Woodworth, Jie Xu +9 morewiley +1 more sourceGenetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak
Animal Research and One Health, EarlyView.Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT
The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen +15 morewiley +1 more sourceUltra‐High‐Efficiency On‐Chip CO2 Conversion by Nanosecond Self‐Pulsing Micro‐Plasma Devices
Carbon Energy, EarlyView.A micro‐plasma chip with sub‐10‐μm electrode gaps is introduced for efficient CO2‐to‐CO conversion. The device self‐converts a DC power supply into nanosecond pulses, producing field‐emission electrons that vibrationally excite CO2, driving dissociation via the ladder‐climbing mechanism. A scaled‐up chip array achieves 30% single‐pass conversion and 50%Guangyu Sun, Bartu Karakurt, Hongkeng Zhu, Onder Soydal, Jeremy S. Luterbacher, Elison Matioli +5 morewiley +1 more sourceImproving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics
International Journal of Cancer, EarlyView.Abstract
Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink +11 morewiley +1 more source
