Results 101 to 110 of about 9,233 (239)

A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6

Case Reports in Medicine, 2019
We report a 37-year-old woman with an out-of-hospital cardiac arrest caused by ventricular fibrillation due to digenic inheritance of long QT syndrome type 2 (KCNH2 gene) and type 6 (KCNE2 gene).
Annejet Heida, Lisette J. M. E. van der Does, Ahmed A. Y. Ragab, Natasja M. S. de Groot   +3 more
doaj   +1 more source

Quinoa Ameliorates High‐Fat Diet‐Induced Obesity in Female Mice by Regulating Gut Microbiota and Adipogenesis

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Quinoa intervention counteracts high‐fat diet (HFD)‐induced obesity in C57BL/6 female mice and elicits a concomitant increase in the relative abundance of Bacteroidota, Bacteroidia, Bacteroidales, and Muribaculaceae. Treatment with quinoa in HFD‐fed female mice results in reduced expression of genes involved in “ion channel” in gonadal white adipose ...
Yingqi Liu, Qiwen Pan, Xiaohua Bao, Yingxin Zhang, Xianjun Liu, Yue Liu, Yujie Liu, Yingxin Zhang, Qirui Xie, Zhiyong Liang, Fengjie Sun, Jing Li, Hao Li, Zhandong Li   +13 more
wiley   +1 more source

ECG-Based Measurements of Drug-induced Repolarization Changes [PDF]

, 2015
The purpose of this thesis is to investigate the abnormal repolarization both in the cellular and the surface ECG along with their relationship. It has been identified that the certain morphological changes of the monophasic action potential are ...
Bhuiyan, Tanveer Ahmed
core   +2 more sources

Analysis of CACNA1C and KCNH2 Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia [PDF]

, 2022
Alexander Refisch, Shoko Komatsuzaki, Martin Ungelenk, Andy Schumann, Ha‐Yeun Chung, Susann S. Schilling, Wibke Jantzen, Sabine Schröder, Markus M. Nöthen, Thomas W. Mühleisen, Christian A. Hübner, Karl‐Jürgen Bär   +11 more
openalex   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Upregulation of Functional Kv11.1a Isoform Expression by Modified U1 Small Nuclear RNA

, 2018
The KCNH2 or human ether-a go-go-related gene (hERG) encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier potassium current in the heart.
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core  

Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China [PDF]

, 2014
BACKGROUND: Individual response to medications varies significantly among different populations, and great progress in understanding the molecular basis of drug action has been made in the past 50 years.
Chao Chen, Hong Wang, Jiayi Zhang, Tianbo Jin, Tingting Geng, Xiaolan Li, Yali Cui, Zulfiya Yunus   +7 more
core   +1 more source

Regulation of Kv11.1 Potassium Channel C-Terminal Isoform Expression by the RNA-Binding Proteins HuR and HuD

, 2018
The potassium voltage-gated channel subfamily H member 2 (KCNH2) gene encodes the Kv11.1 potassium channel, which conducts the rapidly activating delayed rectifier current in the heart.
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core  

G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling [PDF]

, 2015
Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths
Dolatshad, NF, Foldes, G, Harding, SE, Hellen, N, Jabbour, R   +4 more
core   +1 more source

KCNH2 pharmacogenomics summary [PDF]

Pharmacogenetics and Genomics, 2010
Connie, Oshiro, Caroline F, Thorn, Dan M, Roden, Teri E, Klein, Russ B, Altman   +4 more
openaire   +2 more sources