The Sunrise of Tertiary Lymphoid Structures in Cancer
Immunological Reviews, Volume 332, Issue 1, July 2025.ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort +3 more
wiley +1 more source
Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome.
PLoS ONEWe identified two different inherited mutations in KCNH2 gene, or human ether-a-go-go related gene (hERG), which are linked to Long QT Syndrome. The first mutation was in a 1-day-old infant, whereas the second was in a 14-year-old girl.
Anthony Owusu-Mensah +9 more
doaj +1 more source
A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6
Case Reports in Medicine, 2019 We report a 37-year-old woman with an out-of-hospital cardiac arrest caused by ventricular fibrillation due to digenic inheritance of long QT syndrome type 2 (KCNH2 gene) and type 6 (KCNE2 gene).
Annejet Heida +3 more
doaj +1 more source
Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management
Advanced Science, Volume 12, Issue 24, June 26, 2025.Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang +4 more
wiley +1 more source
K⁺ チャネルを調節するKCNE1の頻度の多い遺伝子多型、G38Sの潜在的な病原性について [PDF]
, 2013 富山大学・富医薬博甲第116号・山口由明・2013/09/27・★論文非公開 ...
山口 由明
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Developmental Medicine &Child Neurology, Volume 67, Issue 6, Page 734-739, June 2025.Abstract Sudden deaths in infants and children represent a profound and tragic event that continues to challenge researchers despite extensive investigation over several decades. The predominant phenotype, sudden infant death syndrome (SIDS), has evolved into the broader category of sudden unexpected infant death (SUID).
Suvasini Sharma +3 more
wiley +1 more source
Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies [PDF]
, 2012 To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS ...
Arking, Dan E. +35 more
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Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare KCNH2 Variants [PDF]
, 2021 Krystian A. Kozek +29 more
openalex +1 more source
Epilepsy–heart syndrome: Concept, clinical context, and opportunity for integrated care
Epilepsia, Volume 66, Issue 6, Page 1830-1837, June 2025.Abstract In this concept paper, we introduce epilepsy‐heart syndrome as a shared burden of illness between epilepsy and cardiac disorders. This pragmatic definition is agnostic of which condition came first (the epilepsy or the cardiac disorder), recognising that these conditions can each serve as a risk factor for the other owing to a bidirectional ...
Gashirai K. Mbizvo +3 more
wiley +1 more source
Upregulation of Functional Kv11.1a Isoform Expression by Modified U1 Small Nuclear RNA
, 2018 The KCNH2 or human ether-a go-go-related gene (hERG) encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier potassium current in the heart.
Gong, Qiuming +2 more
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