Results 231 to 240 of about 9,256 (240)

hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk

Current Drug Metabolism, 2008
Testing new compounds for pro-arrhythmic potential has focused in recent years on avoiding activity at the hERG K+ channel, as hERG block is a common feature of many pro-arrhythmic compounds associated with Torsades de Pointes in humans. Blockers of hERG are well known to prolong cardiac action potentials and lead to long QT syndrome, and activators ...
Mark R, Bowlby, Ravi, Peri, Howard, Zhang, John, Dunlop   +3 more
openaire   +2 more sources

Genetic Polymorphism of KCNH2 Confers Predisposition of Acquired Atrial Fibrillation in Chinese

Journal of Cardiovascular Electrophysiology, 2009
Introduction: Nonfamiliar atrial fibrillation (AF) is usually associated with acquired structural heart disease, including valvular heart disease, coronary artery disease, and hypertension. Suggestive evidence indicates that these forms of acquired AF are more likely to occur in individuals with a genetic predisposition.
Qun-Shan, Wang, Xiao-Feng, Wang, Xing-Dong, Chen, Jie-Fei, Yu, Jun, Wang, Jian, Sun, Shang-Biao, Lu, Mu-Yao, Shen, Ming, Lu, Yi-Gang, Li, Li, Jin   +10 more
openaire   +2 more sources

Decoding KCNH2 variants of unknown significance

Heart Rhythm, 2020
Carlos G, Vanoye, Alfred L, George
openaire   +2 more sources

Most LQT-linked KCNH2 mutations are trafficking-defective

Heart Rhythm, 2005
Brian P. Delisle, Corey L. Anderson, Blake D. Anson, Jennifer A. Kilby, Melissa L. Will, David J. Tester, Michael J. Ackerman, Qiuming Gong, Zhengfeng Zhou, Craig T. January   +9 more
openaire   +1 more source

Gene symbol: KCNH2.

Human genetics, 2007
Crotti L, Insolia R, Pedrazzini M, Andreoli C, Gabanti E, Moncalvo C, Crimi G, De Ferrari G, Schwartz PJ.   +8 more
openaire   +3 more sources

Gene symbol: KCNH2. Disease: Long QT syndrome.

Human genetics, 2008
Crotti, L, Pedrazzini, M, Ferrandi, C, Insolia, R, Cuoretti, A, Dagradi, F, Crimi, G, Coto, E, Reguero, JR, Schwartz, PJ.   +9 more
openaire   +5 more sources

Role of a KCNH2 polymorphism (R1047 L) in dofetilide-induced

Journal of Molecular and Cellular Cardiology, 2004
Z SUN, P MILOS, J THOMPSON, D LLOYD, A MANKSEYMOUR, J RICHMOND, J CORDES, J ZHOU   +7 more
openaire   +1 more source

Nouvelle mutation du gène KCNH2 chez une patiente diagnostiquée épileptique

Revue Neurologique, 2014
A. Chanséaume, G. Millat, A. Roux
openaire   +1 more source

Gene Symbol: KCNH2 Disease: Long QT syndrome

2007
Crotti, L, Pedrazzini, M, Ferrandi, C, Insolia, R, Tosin, L, Vicentini, A, Turco, A, De Ferrari, GM, Schwartz, PJ   +8 more
openaire   +1 more source

KCNH2: Role in Cardiac Physiology and Pathophysiology

openaire   +1 more source