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Deletion of Kcnj16 Disturbs Acid-Base Homeostasis in Dahl Salt-Sensitive Rats

Journal of the American Society of Nephrology, 2023
Background: The role of renal inwardly-rectifying potassium (K ir ) channels in regulating acid-base homeostasis has been suggested by various studies.
Biyang Xu   +4 more
semanticscholar   +2 more sources

DNA N6-methyladenine methylase N6AMT1 controls neuropathic pain through epigenetically modifying Kcnj16 in dorsal horn neurons.

Pain, 2023
Nerve injury-induced aberrant changes in gene expression in spinal dorsal horn neurons are critical for the genesis of neuropathic pain. N6-methyladenine (m6A) modification of DNA represents an additional layer of gene regulation.
Hui-Min Zhou   +17 more
semanticscholar   +3 more sources

Seizures and Post-Ictal Respiratory Recovery in Kcnj16−/− Sprague-Dawley Rats

Physiology
Epilepsy is a common neurological disorder (3.5 million in the US), of which ~1/3 continue to experience repeated seizures failing to benefit from anti-seizure medication.
Luke Zangl   +6 more
semanticscholar   +2 more sources

Kcnj16 (Kir5.1) Mutations in Sprague Dawley Rats: Characteristics of SUDEP-Resistant Rat Models of Repeated Seizures

Physiology
Epilepsy is one of the most common neurological disorders, and current anti-seizure medications fail to prevent seizures in ~1/3 of patients. Patients with uncontrolled seizures are at increased risk of Sudden Unexpected Death in Epilepsy (SUDEP ...
Luke Zangl   +6 more
semanticscholar   +2 more sources

lncRNA XIST is associated with preeclampsia and mediates trophoblast cell invasion via miR-340-5p/KCNJ16 signaling pathway.

Transplant Immunology, 2022
Preeclampsia (PE) is a syndrome commonly occurring among the pregnant. Shallow trophoblast invasion is considered to be closely related to PE. Therefore, in trophoblast cells, we explored the potential mechanisms of lncRNA XIST in the modulation of trophoblast invasion and proliferation.GEO online analyzer was used to screen the abnormally expressed ...
Yuling Guo, Yiping Gao, Shasha Liu
semanticscholar   +3 more sources

Acute Flaccid Paralysis Due to KCNJ16 Channelopathy

Indian Journal of Pediatrics
Preeti Joon   +4 more
semanticscholar   +3 more sources

Knockout of Kcnj16 (Kir5.1) in Dahl Salt‐Sensitive Rats Produces Seizure Phenotype

open access: yesThe FASEB Journal, 2018
Kir5.1 is a member of an inwardly rectifying potassium (Kir) channel family notably present in the kidney and brain. We previously established that a knockout rat model of Kcnj16 (gene encoding Kir5.1) on a Dahl salt‐sensitive background (SS Kcnj16−/− )
Anna D. Manis   +4 more
semanticscholar   +2 more sources

KCNJ16-Depleted Kidney Organoids Recapitulate Tubulopathy and Lipid Recovery with Statin Treatment

Journal of the American Society of Nephrology
A. M. van Genderen   +6 more
semanticscholar   +2 more sources

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