Results 21 to 30 of about 1,474 (144)

Cell Settling, Migration, and Stochastic Cancer Gene Expression Suggest Potassium Membrane Flux May Initiate pH Reversal [PDF]

Biomolecules
Attraction of glioblastoma cells to potassium was suspected when glioblastoma cells clustered around dying cells and migrated towards serum (high [K+]) and increased potassium.
Marie E. Beckner
doaj   +2 more sources

Whole-genome sequencing revealed genetic structure, patterns of selection and molecular identity card in “Yufen 1” D line chickens [PDF]

Poultry Science
The “Yufen 1” D line (D) chicken is characterized by strong disease resistance and a high feed conversion rate as a newly bred line. There are few reports on D chicken.
Cong Liu, Jianing Liu, Haishan Guo, Shuangxing Liu, Pingquan Liu, Tingqi Zhu, Wenting Li, Kejun Wang, Xiangtao Kang, Zhunan Li, Guirong Sun   +10 more
doaj   +2 more sources

KCNJ10 Mutations Display Differential Sensitivity to Heteromerisation with KCNJ16 [PDF]

Nephron Physiology, 2013
Background/Aims: Mutations in the inwardly-rectifying K+-channel KCNJ10/Kir4.1 cause autosomal recessive EAST syndrome (epilepsy, ataxia, sensorineural deafness and tubulopathy).
S. Parrock, S. Hussain, N. Issler, A. Differ, N. Lench, S. Guarino, M. Oosterveld, M. Keijzer-Veen, E. Brilstra, H. van Wieringen, A. Y. Konijnenberg, S. Amin-Rasip, Simona Dumitriu, E. Klootwijk, N. Knoers, D. Bockenhauer, R. Kleta, A. Zdebik   +17 more
semanticscholar   +4 more sources

Identification of Driver Epistatic Gene Pairs Combining Germline and Somatic Mutations in Cancer. [PDF]

Int J Mol Sci, 2023
Cancer arises from the complex interplay of various factors. Traditionally, the identification of driver genes focuses primarily on the analysis of somatic mutations.
Rocha J, Sastre J, Amengual-Cladera E, Hernandez-Rodriguez J, Asensio-Landa V, Heine-Suñer D, Capriotti E.   +6 more
europepmc   +3 more sources

Genetic variants in eleven central and peripheral chemoreceptor genes in sudden infant death syndrome. [PDF]

Pediatr Res, 2022
Background: Sudden infant death syndrome (SIDS) is still one of the leading causes of postnatal infant death in developed countries. The occurrence of SIDS is described by a multifactorial etiology that involves the respiratory control system including ...
Neubauer J, Forst AL, Warth R, Both CP, Haas C, Thomas J.   +5 more
europepmc   +2 more sources

Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16)

Experimental physiology, 2011
Inward rectifier (Kir) potassium channels contribute to the control of electrical activity in excitable tissues and their activity is modulated by many biochemical factors, including protons.
S. Trapp, S. Tucker, A. Gourine
semanticscholar   +6 more sources

Kir5.1 regulates Kir4.2 expression and is a key component of the 50-pS inwardly rectifying potassium channel in basolateral membrane of mouse proximal tubules. [PDF]

Am J Physiol Renal Physiol
Kir5.1 encoded by Kcnj16 is an inwardly-rectifying K+ channel-subunit and it possibly interacts with Kir4.2-subunit encoded by Kcnj15 for assembling a Kir4.2/Kir5.1 heterotetramer in the basolateral membrane of mouse proximal-tubule.
Zhang CB, Ding Z, Duan XP, Chowdhury T, Wang WH, Lin DH.   +5 more
europepmc   +2 more sources

Genetic Inactivation of Kcnj16 Identifies Kir5.1 as an Important Determinant of Neuronal PCO2/pH Sensitivity* [PDF]

Journal of Biological Chemistry, 2010
The molecular identity of ion channels which confer PCO2/pH sensitivity in the brain is unclear. Heteromeric Kir4.1/Kir5.1 channels are highly sensitive to inhibition by intracellular pH and are widely expressed in several brainstem nuclei involved in ...
Cristina D’Adamo, L. Shang, P. Imbrici, Steve D. M. Brown, M. Pessia, S. Tucker   +5 more
semanticscholar   +5 more sources

Genetic mutation of Kcnj16 identifies Kir5.1‐containing channels as key regulators of acute and chronic pH homeostasis [PDF]

The FASEB Journal, 2019
Acute and chronic homeostatic pH regulation is critical for the maintenance of optimal cellular function. Renal mechanisms dominate global pH regulation over longer time frames, and rapid adjustments in ventilation compensate for acute pH and CO2 changes.
M. Puissant, C. Muere, V. Levchenko, Anna D. Manis, P. Martino, H. Forster, O. Palygin, A. Staruschenko, M. Hodges   +8 more
semanticscholar   +3 more sources

Protective effects of Maillard products of skipjack trypsin hydrolysate on uric acid-induced injury of human kidney-2 cell (HK-2)

CyTA - Journal of Food
The uric acid (UA) induced damage influences human health and deserves attention. The purpose of this study was to investigate the protective effects of Skipjack trypsin hydrolysate (STH) and its Maillard product (STH-M) and the segmentation of STH-M ...
Yurou Chu, Jiaxing Wang, Jipeng Sun, Ru Song, Liang Chen, Xiaoyu Zou   +5 more
doaj   +2 more sources