Results 31 to 40 of about 1,474 (144)

Altered pH Homeostasis and Acoustic Induced Seizures Associated with Kcnj16 Loss of Function Mutation

The FASEB Journal, 2017
Medullary neurons expressing pH sensitive potassium channels have been proposed to play a role in cellular pH chemosensitivity and CO2/pH homeostasis, but the specific potassium channels that contribute remain to be elucidated.
Nicholas J. Burgraff, T. Pavlov, V. Levchenko, A. Geurts, H. Forster, A. Staruschenko, M. Hodges, O. Palygin   +7 more
semanticscholar   +2 more sources

Effect of Diuretics and Gender on Kcnj16‐mediated Effects in Salt Sensitive Hypertension

The FASEB Journal, 2017
Hypokalemia is a potentially life‐threatening imbalance characterized by a serum potassium concentration of less than 3.5mmol/L (severe hypokalemia < 2.5mmol/L) caused by a deficit in total body potassium stores induced by dietary, genetic or iatrogenic ...
O. Palygin, V. Levchenko, O.O. Prudnikov, Christine K. Nguyen, A. Staruschenko   +4 more
semanticscholar   +2 more sources

Compound Heterozygous Loss of Allele Coding for KCNJ16 in an Adult Presenting as Recurrent Hypokalemic Periodic Paralysis with Metabolic Acidosis and Hypokalemia

Indian Journal of Nephrology
A 20-year-old male presented with fever and rapidly progressive muscle weakness. He had hypokalemia and metabolic acidosis, suggesting renal tubular acidosis (RTA). Further investigation revealed distal RTA with preserved acidification.
M. K. H. Prasad, Renju Binoy, Himanshu Sekhar Mahapatra, D. Akshay   +3 more
semanticscholar   +2 more sources

Role of Kir5.1 (Kcnj16) Channel in the Control of Potassium Homeostasis in the Kidney

The FASEB Journal, 2016
The inwardly‐rectifying potassium (K+) channels (Kir), Kir4.1/Kir5.1 (Kcnj10/Kcnj16) are critical channels responsible for the recycling of K+ in the distal nephron as well as regulation of basolateral membrane potential.
O. Palygin, V. Levchenko, Aron M. Geurts, A. Staruschenko   +3 more
semanticscholar   +2 more sources

Investigating the Causality and Pathogenesis of Primary Sclerosing Cholangitis in Colorectal Cancer Through Mendelian Randomization and Bioinformatics. [PDF]

Genet Res (Camb)
Introduction: The relationship between autoimmune diseases and cancer risk has been increasingly studied. Colorectal cancer, a common malignancy with high morbidity and mortality, has been closely linked to inflammatory bowel disease (IBD) in previous research.
Jiao J, Wang H, Sun D, Yu W.
europepmc   +2 more sources

A novel KCNJ16 kidney organoid model recapitulates the disease phenotype and shows restoration of lipid accumulation upon treatment with statins

bioRxiv, 2023
AbstractBackgroundtheKCNJ16gene has been associated with a novel kidney tubulopathy phenotype,viz.disturbed acid-base homeostasis, hypokalemia and altered renal salt transport.KCNJ16encodes for Kir5.1, which together with Kir4.1 constitutes a potassium channel located at kidney tubular cell basolateral membranes.
E. Sendino Garví, G. V. van Slobbe, E. Zaal, J. D. de Baaij, J. Hoenderop, R. Masereeuw, M. Janssen, A. M. van Genderen   +7 more
semanticscholar   +3 more sources

Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases

Genes and Diseases, 2021
Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by KCNJ16) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by
Junhui Zhang, Jian Han, Lingfei Li, Qiong Zhang, Yanhai Feng, Youzhao Jiang, Fang Deng, Yuping Zhang, Qinan Wu, Bing Chen, Jiongyu Hu   +10 more
doaj   +1 more source

Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis

Physiological Reports, 2021
The nitric oxide (NO)‐generating enzyme, NO synthase‐1β (NOS1β), is essential for sodium (Na+) homeostasis and blood pressure control. We previously showed that collecting duct principal cell NOS1β is critical for inhibition of the epithelial sodium ...
Kelly A. Hyndman, Elena Isaeva, Oleg Palygin, Luciano D. Mendoza, Aylin R. Rodan, Alexander Staruschenko, Jennifer S. Pollock   +6 more
doaj   +1 more source

The effect of high-dietary K+ (HK) on Kir4.1/Kir5.1 and ROMK in the distal convoluted tubule (DCT) is not affected by gender and Cl− content of the diet

Frontiers in Physiology, 2022
Basolateral potassium channels in the distal convoluted tubule (DCT) are composed of inwardly-rectifying potassium channel 4.1 (Kir4.1) and Kir5.1. Kir4.1 interacts with Kir5.1 to form a 40 pS K+ channel which is the only type K+ channel expressed in the
Xin-Xin Meng, Hao Zhang, Gui-Lin Meng, Shao-Peng Jiang, Xin-Peng Duan, Wen-Hui Wang, Ming-Xiao Wang   +6 more
doaj   +1 more source

Transcriptomic analysis of the developing and adult mouse cochlear sensory epithelia [PDF]

, 2012
International audienceThe adult mammalian cochlea lacks regenerative ability and the irreversible degeneration of cochlear sensory hair cells leads to permanent hearing loss.
Assou, Said, Masmoudi, Saber, Savary, Etienne, Smeti, Ibtihel, Zine, Azel   +4 more
core   +14 more sources