Results 71 to 80 of about 1,474 (144)

The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability. [PDF]

, 2016
The heart is controlled by the sympathetic and parasympathetic limbs of the autonomic nervous system with inhibitory signaling mechanisms recruited in both limbs.
Aziz, Bowman, Boychuk, Carmichael, Desai, Dolphin, Finlay, Guyenet, Head, Horiuchi, Izzo, LaVallie, Lopez, Luscher, Ma, Machhada, Madden, Madden, Marina, Marina, Nalivaiko, Nalivaiko, Ng, Ngampramuan, Nolan, Onodera, Parker, Paton, Paton, Richter, Rong, Schreihofer, Sebastian, Spyer, Sternweis, Strack, Trapp, Ustyugova, Vaseghi, Verrier, Wainford, Zuberi, Zuberi   +42 more
core   +2 more sources

Uncovering covariance patterns across energy balance traits enables the discovery of new obesity‐related genes

Obesity, Volume 33, Issue 6, Page 1184-1194, June 2025.
Abstract Objective Effective solutions to obesity remain elusive, partly owing to its root in a positive energy balance (EB), which stems from the interplay of numerous traits spanning body size and composition, diet, physical activity, and metabolic profile. Nevertheless, EB‐contributing traits are typically studied in isolation. We integrate numerous
Davorka Gulisija, Agustin Gonzalez‐Reymundez, Jenifer I. Fenton, Gustavo de los Campos, Molly S. Bray, Ana I. Vazquez   +5 more
wiley   +1 more source

Repeated seizures lead to progressive ventilatory dysfunction in SS<i>^Kcnj16-/-</i> rats.

J Appl Physiol (1985), 2023
This study demonstrated that repeated seizures in a novel rat model (SS Kcnj16−/− rats) caused a progressively greater ventilatory dysfunction in the immediate postictal period associated with brainstem serotonin (5-HT) suppression. Augmenting brain 5-HT with a selective serotonin reuptake inhibitor prevented the progressive ventilatory dysfunction ...
Manis AD, Cook-Snyder DR, Duffy E, Osmani WA, Eilbes M, Dillard M, Palygin O, Staruschenko A, Hodges MR.   +8 more
europepmc   +3 more sources

Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron. [PDF]

, 2018
Kir4.1/5.1 heterotetramer participates in generating the negative cell membrane potential in distal convoluted tubule (DCT) and plays a critical role in determining the activity of Na-Cl cotransporter (NCC).
Gao, Z.X., Lin, D.H., Staub, O., Su, X.T., Wang, M.X., Wang, W.H., Wu, P.   +6 more
core   +1 more source

Caractérisation des canaux potassiques du tubule contourné proximal et des propriétés régulatrices des canaux chlorure de la membrane basolatérale des cellules intercalaires du tubule connecteur [PDF]

, 2015
A 10 pS chloride channel at the basolateral side of connecting duct intercalated cells shares properties with the cloned ClC-K2 channel. Patch-clamp experiments show that its activity and the number of active channels increase with (i) membrane ...
Pinelli, Laurent
core   +2 more sources

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. [PDF]

, 2020
Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two ...
Draf, Clara, Fisch, Kathleen M, Kurabi, Arwa, Nasamran, Chanond A, Pak, Kwang, Ryan, Allen F, Webster, Nicholas   +6 more
core  

Genetic Analysis of 17q Terminal Partial Trisomy

Clinical Case Reports, Volume 12, Issue 12, December 2024.
ABSTRACT Chromosomal trisomy syndrome is associated with diverse clinical phenotypes, including intellectual disability. Partial trisomy of the distal 17q is a rare anomaly with similar clinical features, including psychomotor and growth deficits, facial dysmorphism, and microcephaly.
Huiling Zheng, Lin Zheng, Zhi Huang, Guangping Li, Daili Tang, Xue Yang, Tian Tian   +6 more
wiley   +1 more source

Potassium channels in epithelial transport [PDF]

, 2018
Epithelial cells in the kidney, gastrointestinal tract and exocrine glands are engaged in vectorial transport of salt and nutrients. In these tissues, K+ channels play an important role for the stabilization of membrane voltage and maintenance of the ...
Warth, Richard
core  

The Concise Guide to PHARMACOLOGY 2015/16:Voltage-gated ion channels [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
,, Alexander, Stephen Ph, Benson, Helen E, Catterall, William A, Davies, Jamie A, Faccenda, Elena, Kelly, Eamonn, Marrion, Neil, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +4 more sources

Melatonin protects Kir2.1 function in an oxidative stress‐related model of aging neuroglia

BioFactors, Volume 50, Issue 3, Page 523-541, May/June 2024.
The inward rectifying K+ channel Kir2.1 plays a major role in extracellular potassium buffering in the brain. Here we show that in cellular models of aging neuroglia characterized by an elevated oxidative stress, the Kir2.1‐induced current is dramatically reduced. This loss of function resulted from a reduction in protein abundance, with no alterations
Alessia Remigante, Sara Spinelli, Paolo Zuccolini, Paola Gavazzo, Angela Marino, Michael Pusch, Rossana Morabito, Silvia Dossena   +7 more
wiley   +1 more source