Results 81 to 90 of about 1,474 (144)

Genomic predictions and GWAS for heat tolerance in pigs based on reaction norm models with performance records and data from public weather stations considering alternative temperature thresholds

Journal of Animal Breeding and Genetics, Volume 141, Issue 3, Page 257-277, May 2024.
Abstract Genetic improvement of livestock productivity has resulted in greater production of metabolic heat and potentially greater susceptibility to heat stress. Various studies have demonstrated that there is genetic variability for heat tolerance and genetic selection for more heat tolerant individuals is possible. The rate of genetic progress tends
Pedro Henrique F. Freitas, Jay S. Johnson, Francesco Tiezzi, Yijian Huang, Allan P. Schinckel, Luiz F. Brito   +5 more
wiley   +1 more source

Astrocyte‐like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells

Glia, Volume 72, Issue 2, Page 245-273, February 2024.
Main Points Subpopulations of NG2 glia in the healthy and ischemic adult cortex were identified based on their gene expression and membrane properties. Astrocyte‐like NG2 glia exhibit neurogenic gene expression and are more abundant in post‐ischemic tissue.
Lucie Janeckova, Tomas Knotek, Jan Kriska, Zuzana Hermanova, Denisa Kirdajova, Jan Kubovciak, Linda Berkova, Jana Tureckova, Sara Camacho Garcia, Katerina Galuskova, Michal Kolar, Miroslava Anderova, Vladimir Korinek   +12 more
wiley   +1 more source

Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy [PDF]

, 2016
Dysfunction of the inwardly-rectifying potassium channels Kir4.1 (KCNJ10) represents a pathogenic mechanism contributing to Autism-Epilepsy comorbidity.
Ambrosini, Elena, Baldini, Sara, Brignone, Maria Stefania, Catacuzzeno, Luigi, D'Adamo, Maria Cristina, Franciolini, Fabio, Grottesi, Alessandro, Hasan, Sonia M., Lanciotti, Angela, Marchese, Maria, Molinari, Paola, Moro, Francesca, Pessia, Mauro, Santorelli, Filippo Maria, Servettini, Ilenio, Sforna, Luigi, Sicca, Federico, Valvo, Giulia   +17 more
core   +1 more source

A comprehensive analysis of gene expression profiles in distal parts of the mouse renal tubule [PDF]

, 2018
The distal parts of the renal tubule play a critical role in maintaining homeostasis of extracellular fluids. In this review, we present an in-depth analysis of microarray-based gene expression profiles available for microdissected mouse distal nephron ...
Bonny, Olivier, Centeno, Gabriel, Firsov, Dmitri, Pradervand, Sylvain, Zuber Mercier, Annie   +4 more
core  

Molecular bases of K+ secretory cells in the inner ear: shared and distinct features between birds and mammals [PDF]

, 2016
In the cochlea, mammals maintain a uniquely high endolymphatic potential (EP), which is not observed in other vertebrate groups. However, a high [K+] is always present in the inner ear endolymph.
Hartmann, Anna-Maria, Köppl, Christine, Nothwang, Hans Gerd, Söffgen, Chris, Wilms, Viviane   +4 more
core  

Ion channel expression in human melanoma samples. in silico identification and experimental validation of molecular targets [PDF]

, 2019
Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e., about 28%) show a significant (p 0.90 and p 90% in most cases).
D’Arcangelo, Daniela, Facchiano, Antonio, Facchiano, Francesco, Giampietri, Claudia, Marchetti, Paolo, Scatozza, Francesca   +5 more
core   +1 more source

Essential role of Kir5.1 channels in renal salt handling and blood pressure control.

JCI Insight, 2017
Supplementing diets with high potassium helps reduce hypertension in humans. Inwardly rectifying K+ channels Kir4.1 (Kcnj10) and Kir5.1 (Kcnj16) are highly expressed in the basolateral membrane of distal renal tubules and contribute to Na+ reabsorption ...
O. Palygin, V. Levchenko, D. Ilatovskaya, T. Pavlov, O. Pochynyuk, H. Jacob, A. Geurts, M. Hodges, A. Staruschenko   +8 more
semanticscholar   +1 more source

Additional file 1 of KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment

Additional file 1. Figure S1. Schematic representation of the generation of KCNJ16 knockouts in iPSCs. The iPSCs KCNJ16WT were nucleofected with a gRNA targeting a genomic region of exon 5 of the KCNJ16 gene with an average knockout efficiency score on the pooled population of 75% (N=3).
Sendino Garví, E., van Slobbe, G. J. J., Zaal, E. A., de Baaij, J. H. F., Hoenderop, J. G., Masereeuw, R., Janssen, M. J., van Genderen, A. M.   +7 more
openaire   +1 more source

Abstracts

Molecular Oncology, Volume 18, Issue S1, Page 1-495, June 2024.
wiley   +1 more source

Development of cochlear spiral ligament fibrocytes of the common marmoset, a nonhuman model animal. [PDF]

Sci Rep, 2023
Hosoya M, Iwabu K, Kitama T, Nishiyama T, Oishi N, Okano H, Ozawa H.   +6 more
europepmc   +1 more source