Results 51 to 60 of about 4,086 (181)

Polymorphic ventricular tachycardia with mutation in KCNJ2: case report

Frontiers in Cardiovascular Medicine
Polymorphic ventricular tachycardia (VT), particularly in the absence of structural heart disease, has a strong genetic foundation primarily rooted in mutations affecting cardiac ion channels and associated regulatory proteins.
Cuizhen Zhou, Juan Chen, Cuilan Hou, Tingting Xiao, Li Zhang   +4 more
doaj   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Novel KCNJ2 Mutation in Familial Periodic Paralysis With Ventricular Dysrhythmia [PDF]

Circulation, 2002
Background — Mutations in the KCNJ2 gene, which codes cardiac and skeletal inward rectifying K + channels (Kir2.1), produce Andersen’s syndrome, which is characterized
Tomohiko, Ai, Yuichiro, Fujiwara, Keiko, Tsuji, Hideo, Otani, Shozo, Nakano, Yoshihiro, Kubo, Minoru, Horie   +6 more
openaire   +2 more sources

Obstructive Sleep Apnea and Circulating Potassium Channel Levels

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundCardiac arrhythmias and sudden cardiac death are more frequent in patients with obstructive sleep apnea (OSA). OSA is associated with QT prolongation, and QT prolongation is an independent risk factor for sudden cardiac death.
Ning Jiang, Anyu Zhou, Bharati Prasad, Li Zhou, Jimmy Doumit, Guangbin Shi, Hafiz Imran, Bahaa Kaseer, Richard Millman, Samuel C. Dudley   +9 more
doaj   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Quantitative PCR for total Hcn4 and Kcnj2 genes.

, 2015
A. Relative expression of total Hcn4 gene. HCN4-overexpressing mESC-CMs expressed about 3-times higher mRNA levels of total Hcn4 than did EGFP mESC-CMs. B. Relative expression of Kcnj2 gene.
Hiroshi Morita (124362), Yukihiro Saito (797587), Satoshi Nagase (351216), Kazufumi Nakamura (336712), Makoto Takano (371653), Hiroki Sugiyama (351211), Junko Kurokawa (253979), Tetsushi Furukawa (253981), Masashi Yoshida (227874), Tohru Ohe (351219), Kengo F. Kusano (797588), Hiroshi Ito (297745)   +11 more
core   +1 more source

Generation of a human PBMC induced pluripotent stem cell line JXEYi001-A-iPSC from a pediatric patient with ventricular arrhythmias

Stem Cell Research
This study established an iPSC line, JXEYi001-A, from a 7-year-old male with a KCNJ2 mutation linked to ventricular arrhythmias (VA). KCNJ2 encodes Kir2.1, essential for cardiac repolarization; its mutations can cause short QT syndrome, increasing VA ...
Yunguo Zhou, Yang Shen, Keyu Jiang, Fei Xu, Junkai Duan, Jinzhu Hu   +5 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Intrauterine exposure to nicotine through maternal vaping disrupts embryonic lung and skeletal development via the Kcnj2 potassium channel.

, 2023
Smoking cigarettes during pregnancy is associated with adverse effects on infants including low birth weight, defective lung development, and skeletal abnormalities.
Vladar, Eszter K, Bates, Emily A, Saal, Maxwell L, Pineda, Ricardo H, Moehn, Kayla, Korth, Kamryn M, Ordonez-Erives, Madison A, Königshoff, Melanie, Ozekin, Yunus H, Delgado Figueroa, Maria F, Frazier, Caleb   +10 more
core   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source