Results 81 to 90 of about 4,086 (181)

Cardiac Manifestations of KCNK17 Mutations and/or Polymorphisms: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims The KCNK17 gene encodes k2p17.1 channels (TASK‐4 or TALK‐2) with dominant expressions in the atria and the Purkinje fibers. Emerging studies have suggested possible associations between KCNK17 variants and cardiovascular as well as cerebrovascular diseases. This review aimed to systematically evaluate the evidence on KCNK17
Amir Askarinejad, Mahshid Malakootian, Dorsa Shekouh, Amirreza Sabahizadeh, Majid Haghjoo   +4 more
wiley   +1 more source

Functional expression of inwardly rectifying and ATP‐sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells

The Journal of Physiology, Volume 604, Issue 5, Page 1820-1839, 1 March 2026.
Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Bianca Barreira, Daniel Morales‐Cano, Laura Moreno, Beatriz de Olaiz, Rui Adão, Angel Cogolludo, Francisco Perez‐Vizcaino, Maria Sancho   +7 more
wiley   +1 more source

Multi‐Omics Analysis Reveals Sex‐Specific Signatures for BCG Vaccine Efficacy

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Sex‐specific pre‐vaccination immune landscapes associated with effective BCG vaccine responses. Male high responders exhibit a monocyte‐enriched, pro‐inflammatory innate immune profile, whereas female high responders display immune signatures associated with enhanced adaptive immune responses. ABSTRACT Vaccines are a cornerstone of global public health,
Qiuyao Zhan, Liang Zhou, Jianbo Fu, Xun Jiang, Xuan Liu, Wenchao Li, Simone J.C.F.M. Moorlag, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Vera P. Mourits, Leo A.B. Joosten, Yang Li, Mihai G. Netea, Cheng‐Jian Xu   +13 more
wiley   +1 more source

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy [PDF]

, 2014
Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post-partum haemorrhage.
Dale, T, Nan Lin, Brown, Pamela, England, Sarah, Pamela Brown, Jeff Jerman, McCavera, Samantha, Rand, DA, Tickle, D, Kettleborough, Catherine, McCavera, S, Brosens, Jan, Taggart, MJ, Chan, YW, Trezise, Derek J., Catherine Kettleborough, Manu Vatish, Denton, JS, Jerod S Denton, van den Berg, HA, Siobhan Quenby, Atia, Jolene, Cara Rada, England, Sarah K, Rada, C, Rada, Cara, Rand, David A., Shmygol, A, Catalano, R, Vatish, M, Brown, P, van den Berg, Hugo A., Dale, Timothy, David A Rand, Michael J Taggart, Kettleborough, C, McCloskey, C., Lin, Nan, McCloskey, C, Bailey, Elizabeth H., Chan, Yi-Wah, Vatish, Manu, Jerman, J, Andrew M Blanks, Sarah K England, Tickle, David, Berg, Hugo van den, Kanumilli, S, Shmygol, Anatoly, England, Sarah K., Quenby, S, Chan, Y-W, Srinivasan Kanumilli, Steve Thornton, Conor McCloskey, Timothy Dale, Zhang, J, Kanumilli, Srinivasan, David Tickle, Catalano, Roberto D., Atia, J, Yi‐Wah Chan, Jan J Brosens, England, S., Trezise, Derek, Paul Wright, Trezise, DJ, Jie Zhang, Roberto Catalano, Quenby, Siobhan, Bailey, Elizabeth, Derek J Trezise, Brosens, Jan J., McCloskey, Conor, Jerman, Jeff, England, SK, Denton, Jerod S., Zhang, Jie, Brosens, JJ, et al,, Wright, P, Thornton, S, Thornton, Steven, Hugo A van den Berg, Jolene Atia, Taggart, Michael J., Blanks, Andrew M., van den Berg, H. A., Thornton, Steve, Catalano, Roberto, Blanks, AM, Samantha McCavera, Rand, D. A., Blanks, Andrew, Denton, Jerod, Lin, N, Taggart, Michael, Wright, Paul, Bailey, E, Elizabeth Bailey, Anatoly Shmygol   +100 more
core   +1 more source

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability

Glia, Volume 74, Issue 2, February 2026.
Astrocytic TCF7L2 impacts extracellular glutamate and glutamine levels. Loss of astrocytic TCF7L2 disrupts extracellular potassium clearance. TCF7L2‐dependent astrocytic changes reduce neuronal excitability. ABSTRACT Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal ...
Mariusz Popek, Krzysztof Goryca, Dorota Adamska, Joanna Urban‐Ciećko, Katarzyna Hryniewiecka, Marcin Lipiec, Tomasz Grzegorz Krawczyk, Kamil Rafalko, Alicja Ławicka, Shane A. Liddelow, Lukasz Mateusz Szewczyk   +10 more
wiley   +1 more source

Multivariate models of Kir2.1 (KCNJ2) and Connexin 26 (GJB2) protein expression from peripheral CD4+ T cells in relation to HIV unspliced RNA among 40 participants.

, 2023
Multivariate models of Kir2.1 (KCNJ2) and Connexin 26 (GJB2) protein expression from peripheral CD4+ T cells in relation to HIV unspliced RNA among 40 participants.
Rebecca Hoh (283494), Germán G. Gornalusse (9433778), Florian Hladik (346276), Sulggi A. Lee (10013636), Pavitra Roychoudhury (4720350), David A. Siegel (8375748), Frederick Hecht (283496), Michael P. Busch (7387907), Julieta Reppetti (17481087), Steven G. Deeks (6702725), Alton Barbehenn (17481081), Erica A. Gibson (4576492), Timothy J. Henrich (17481093), Claire N. Levy (3167112), Christopher Pilcher (586358), Mars Stone (469986), Jeffrey Martin (553260), Tony Pan (17481084), Cassandra Thanh (4576510), Kristen S. Hobbs (4576495), Ashok K. Dwivedi (17481078), Jeffrey Milush (5780147), Keith R. Jerome (9353956), Meei-Li Huang (342097), Phuong M. Vo (17481090)   +24 more
core   +1 more source

#51 From Paralysis to Heart Block: A Diagnostic Challenge in Andersen-Tawil Syndrome

Graduate Medical Education Research Journal
Mentor: Jeffrey Robinson Program: Pediatrics – Cardiology Type: Case Report Background: Andersen-Tawil Syndrome (ATS) is a rare genetic disorder caused by mutations in the KCNJ2 gene, which encodes Kir2.1 potassium channels, resulting in the triad of ...
Andrew Nguyen, Danita Velasco, Jeffrey Robinson   +2 more
doaj   +1 more source

Function, Subcellular Localization and Assembly of a Novel Mutation of KCNJ2 in Andersen's Syndrome [PDF]

Andersen’s syndrome, which is characterized by periodic paralysis, cardiac arrhythmias and dysmorphic features, is a hereditary disease, and missense mutations of KCNJ2, which encodes an inward rectifying potassium channel, have been reported recently ...
6780, 6782, 6781, Aizawa, Yoshifusa, 6784, 6783, Chinushi, Masaomi, Washizuka, Takashi, Hosaka, Yukio, Yoshida, Tsuyoshi, 6777, 6776, 6779, 6778, Komura, Satoru, Hanawa, Haruo, Watanabe, Hiroshi, Yamashita, Fumio   +17 more
core  

Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome

Journal of Arrhythmia, 2012
Andersen-Tawil syndrome (ATS), also known as long QT syndrome type 7, is a rare autosomal dominant disease caused by a KCNJ2 mutation. The characteristic triad of ATS is periodic paralysis, dysmorphic features, and ventricular arrhythmia.
Chizuko A. Kamiya, Wataru Shimizu, Yoshinari Kabayashi, Takekazu Miyoshi, Chinami Horiuchi, Takashi Umekawa, Kaoru Yamanaka, Reiko Neki, Shinji Katsuragi, Jun Yoshimatsu, Tomoaki Ikeda   +10 more
doaj   +1 more source

Biophysical and Molecular Characterization of a Novel De Novo KCNJ2 Mutation Associated With Andersen-Tawil Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia Mimicry

, 2011
Background— Mutations in KCNJ2 , the gene encoding the human inward rectifier potassium channel Kir2.1 (I K1 or I Kir2.1 ), have ...
Elena Burashnikov, Hector Barajas-Martinez, Mayurika Desai, Jorge Scaglione, Charles Antzelevitch, Gustavo Ontiveros, Gabriel Caceres, Dan Hu   +7 more
core   +1 more source