Results 61 to 70 of about 1,102,957 (280)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Simgesel Bir Form Olarak Perspektiften Dinin Seküler İnşasına Mekânın Poetikası

Eskiyeni, 2020
15. yüzyılda, Alberti ve Brunelleschi’nin ortak çabalarıyla ressama özgü perspektifin keşfi, modern mekân kavramında ve onu hayata geçirmede uygulanan modern yön-temlere giden uzun yolda belirleyici bir adım ve gerçek bir dönüm noktası olmuştur.
İrfan Kaya
doaj   +1 more source

Midwest Technology Assistance Center for Small Public Water Systems Final Report [PDF]

, 2010
The Midwest Technology Assistance Center (MTAC) was established October 1, 1998 to provide assistance to small public water systems throughout the Midwest via funding from the United States Environmental Protection Agency (USEPA) under section 1420 ...
Smothers, Kent W., Warner, Richard E., Wilson, Steven D.   +2 more
core  

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

KENT TURİZMİNİN MARKA KENT OLUŞUMUNDAKİ ETKİSİ: ÇANAKKALE KENT TURİZMİNİN SWOT ANALİZİ

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2019
Günümüzde çevrede meydana gelen değişim, insanların yaşam ve davranışları üzerinde önemli etkiler oluşturmaktadır. Yaşanan bu değişiklikler ile insanlar farklı kentlere gidip yeni deneyimler kazanmak istemişlerdir. Dar kalıplara sığdırılmış turizmin çevre, yerli halk ve ziyaretçiler arasında etkileşimini uzun bir süreye yaymak için farklı turizm ...
TEMİZ, Merve, SAĞLIK, Alper, SAĞLIK, Elif, KELKİT, Abdullah, BAYRAK, Mehmet İlkan   +4 more
openaire   +3 more sources

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

Advanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet, Priyanka Kumari, Sathyanarayana Paladugu, Damian Pociecha, Jakub Karcz, Przemysław Kula, Nataša Vaupotič, Ewa Górecka, Oleg D Lavrentovich   +8 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that preces the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

KENT KONSEYLERİNİN BELEDİYE MECLİSLERİNDE GÜNDEM BELİRLEMEDEKİ ETKİSİ: ANTALYA, AFYONKARAHİSAR VE BURDUR ÖRNEĞİ

Mehmet Akif Ersoy Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2016
Bu çalışmanın amacı; yerel yönetişimin bir göstergesi olarak, kent konseylerinin belediye meclislerinin gündeminin belirlenmesindeki etkisini incelemektir.
Mustafa Lamba, Uysal Kerman
doaj   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Yeni Kentlesme Sürecinde Düzce’de Bazı Sorunlar Ve Öneriler

Düzce University Faculty of Forestry Journal of Forestry, 2010
21. yüzyıl çağdas yasamının getirileri doğrultusunda ilerleyen ve daha çok endüstriyel gelismelerinağırlık kazandığı kentlesme sürecinde bazı sorunlar da ortaya çıkmaktadır.
Güniz Akıncı Kesim
doaj