Results 111 to 120 of about 430,959 (308)
Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood +6 more
wiley +2 more sources
Abstract An ecological model was developed to examine the pathways linking immigration state policies to physically safe work conditions and work volition, interpersonal discrimination, and mental health distress. The ecological framework was tested among two subsamples totaling 529 Latinx immigrant participants: (1) immigrants who resided in states ...
Germán A. Cadenas +6 more
wiley +1 more source
Carbonate species play a previously overlooked role in near‐neutral seawater electrocatalysis. By coupling electrochemical hydrodynamics with mesoscopic simulations, we reveal a plausible carbonate‐mediated route in which carbonate functions as an interfacial proton acceptor and water as the oxygen donor, showing a possible mechanistic picture of ...
Miao Wang +2 more
wiley +2 more sources
ABSTRACT Introduction Accurate assessment of heat strain at initial stay time (IST; core temperature 38.0°C or Δ1.0°C above resting), when heat mitigation decisions are required, is critical for managing occupational heat exposure. We evaluated the relationship and agreement between physiological (Physiological Strain Index [PSI] and adaptive PSI [aPSI]
Gil Bourgois +4 more
wiley +1 more source
The Kent Historian, Kent Historical Society Newsletter, Number 85, Summer 2015
THE KENT HISTORIAN The Newsletter of the Kent Historical Society Summer 2015 Number85 Campaign seeks to bring Kent history to the world Funds would allow digitization of newspapers from early 1900s Newspapers are fragile.
core
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster +13 more
wiley +2 more sources
ABSTRACT Introduction Work‐rest allocations recommended by the American Conference of Governmental Industrial Hygienists (ACGIH) limit heat strain and are typically implemented from the onset of work. Whether delaying implementation until after the initial stay time (IST; the duration of continuous work before core temperature reaches 38.0°C) improves ...
Glen P. Kenny +6 more
wiley +1 more source
Kent Arşivi Kültürü İhtiyacımız
Kentler; kendi sınırları ve bu sınırlar içerisinde kendi normatif değerleri ile inançları olan ve belirli sosyal ilişkiler sistemiyle oluşmuş yerleşim yerleridir.
Yasin Şeşen
doaj
KENT TURİZMİNİN MARKA KENT OLUŞUMUNDAKİ ETKİSİ: ÇANAKKALE KENT TURİZMİNİN SWOT ANALİZİ
Günümüzde çevrede meydana gelen değişim, insanların yaşam ve davranışları üzerinde önemli etkiler oluşturmaktadır. Yaşanan bu değişiklikler ile insanlar farklı kentlere gidip yeni deneyimler kazanmak istemişlerdir. Dar kalıplara sığdırılmış turizmin çevre, yerli halk ve ziyaretçiler arasında etkileşimini uzun bir süreye yaymak için farklı turizm ...
TEMİZ, Merve +4 more
openaire +3 more sources

