Results 91 to 100 of about 73,186 (252)

UPDATED MOLECULAR GENETICS AND PATHOGENESIS OF ICHTHYOSES [PDF]

open access: yes, 2011
2011-08Research into the molecular genetics and pathomechanisms of ichthyoses have advanced considerably, resulting in the identification of several causative genes and molecules underlying the disease.
42169, AKIYAMA, MASASHI
core  

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

open access: yesAdvanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin   +10 more
wiley   +1 more source

A novel and ancient group of type I keratins with members in bichir, sturgeon and gar

open access: yesFrontiers in Zoology, 2007
1. Background Vertebrate epithelial cells typically express a specific set of keratins. In teleosts, keratins are also present in a variety of mesenchymal cells, which usually express vimentin.
Neumann Sebastian   +4 more
doaj   +1 more source

New consensus nomenclature for mammalian keratins [PDF]

open access: yes, 2006
Keratins are intermediate filament–forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point.
Bowden, Paul E.   +10 more
core   +2 more sources

Gravity‐Tolerant In‐Flight 3D Bioprinting Enabled by Stereolithography for Space Tissue Engineering

open access: yesAdvanced Science, EarlyView.
A flight‐compliant, closed stereolithographic 3D bioprinting system enables robust fabrication of acellular and cell‐laden hydrogel constructs under varying gravitational conditions, including microgravity and hypergravity phases. Printed structures retain dimensional fidelity and high‐resolution features, while cell viability remains high ...
Bianca Lemke   +8 more
wiley   +1 more source

Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release

open access: yesJournal of Nanobiotechnology, 2018
Background Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications and drug delivery.
Zhongjun Cheng   +8 more
doaj   +1 more source

A “Hot Spring” Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
The SrCuSi4O₁₀ bioceramic particles mimic the effects of hot spring therapy by increasing the local wound temperature, which enhances the absorption of amino acids and stimulates cell metabolism. The amino acid uptake supports cellular glutathione redox reactions, helping to mitigate oxidative stress.
Bo Li   +7 more
wiley   +1 more source

Definition of critical skin defect and concepts of structural and functional repairs: Proposal and verification in a rat model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the research process regarding skin defect repair using a rat model of skin defect. First, it assesses whether the barrier function of the skin is repaired. If the answer is “YES”, the study proceeds to focus on structural repair.
Cong Sun   +6 more
wiley   +1 more source

Molecular and Physiological Basis for Hair Loss in \u3cem\u3eNear Naked Hairless\u3c/em\u3e and \u3cem\u3eOak Ridge Rhino-like\u3c/em\u3e Mouse Models: Tracking the Role of the \u3cem\u3eHairless\u3c/em\u3e Gene [PDF]

open access: yes, 2006
Hairless mice have been widely used in basic research and clinical trials. Two new mouse mutants with hair loss arose spontaneously in the breeding colony of Oak Ridge National Laboratory.
Liu, Yutao
core   +1 more source

Recent advances in animal models for pathological scar research: A comprehensive review of experimental approaches and translational relevance

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Animal models remain indispensable in the study of pathological scars, each offering unique advantages and constraints. Their integration with in vitro and ex vivo systems is key to developing personalized, clinically translatable antifibrotic therapies. Abstract Pathological scarring, manifested in the form of hypertrophic scars (HTS) and keloid scars
Diana‐Larisa Ancuța   +3 more
wiley   +1 more source

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