Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation
JCI Insight, 2023 Keratin (K) and other intermediate filament (IF) protein mutations at conserved arginines disrupt keratin filaments into aggregates and cause human epidermolysis bullosa simplex (EBS; K14-R125C) or predispose to mouse liver injury (K18-R90C).
Jingyuan Sun +9 more
doaj +1 more source
Applied Sciences, 2021 In this work, feather keratin was extracted from the waste feather of chicken via alkyd pretreatment and reduction method, the extraction rate is above 85%. The molecular weight and aggregation morphology of feather keratin in an aqueous environment were
Sujuan Pan +3 more
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CARD14 gain-of-function mutation alone is sufficient to drive IL-23/IL-17-mediated psoriasiform skin inflammation in vivo [PDF]
, 2018 Rare autosomal dominant mutations in the gene encoding the keratinocyte signaling molecule, Caspase Recruitment Domain-Containing Protein 14 (CARD14), have been associated with an increased susceptibility to psoriasis but the physiological impact of ...
Cheng, Phil +11 more
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Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice
International Journal of Genomics, 2018 Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism increase Hcy-thiolactone, which causes protein damage by forming isopetide bonds with lysine residues, generating N-Hcy-protein.
Kamila Borowczyk +5 more
doaj +1 more source
Scientific Reports, 2022 Electrospinning nanofibers have a tremendous interest in biomedical applications such as tissue engineering, drug administration, and wound healing because of their ability to replicate and restore the function of the natural extracellular matrix found ...
Eman Serag +3 more
doaj +1 more source
Potential use of human hair shaft keratin peptide signatures to distinguish gender and ethnicity [PDF]
PeerJ, 2020 Background Most human hairs collected at old crime scenes do not contain nuclear DNA and are therefore of less value for forensic investigations. In the present study, hair shaft proteins were extracted from 40 healthy subjects between the ages of 21 to ...
Nurdiena Mohamed Nasir +3 more
doaj +2 more sources
Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane [PDF]
, 1995 The sorting of apical and basolateral proteins into vesicular carriers takes place in the trans-Golgi network (TGN) in MDCK cells. We have previously analyzed the protein composition of immunoisolated apical and basolateral transport vesicles and have ...
Fiedler, K. +3 more
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Sustainable Management of Keratin Waste Biomass: Applications and Future Perspectives
Brazilian Archives of Biology and Technology, 2016 Keratin is a durable, fibrous protein which is mainly present in higher vertebrates (mammals, birds and reptiles) and humans epithelial cells. Food industry especially the meat market, slaughter house and wool industry produces million of tons of keratin
Swati Sharma, Arun Gupta
doaj +1 more source
Gene expression divergence and nucleotide differentiation between males of different color morphs and mating strategies in the ruff [PDF]
, 2012 By next generation transcriptome sequencing, it is possible to obtain data on both nucleotide sequence variation and gene expression. We have used this approach (RNA-Seq) to investigate the genetic basis for differences in plumage coloration and mating ...
Altschul +63 more
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Nanomaterials, 2023 Hydrotalcites (HTlcs) are a class of nanostructured layered materials that may be employed in a variety of applications, from green to bio technologies.
Franco Dinelli +7 more
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