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Ophthalmologica, 2013 Neurotrophic keratitis (NK) is a rare degenerative corneal disease that occurs as a result of partial or total impairment of trigeminal innervations, leading to a reduction (hypoesthesia) in or loss (anaesthesia) of corneal sensitivity. The impairment of sensory innervation causes a reduction in the lacrimation reflex and the vitality, metabolism and ...
SEMERARO, Francesco +7 more
openaire +5 more sources
British Journal of Ophthalmology, 1994 We read with interest the report by Radford et al on the incidence of acanthamoeba keratitis and the suggested relation with hardness of water.1 However, we disagree with their findings and believe their study is flawed for two reasons. This paper discusses the flaws.
Seal, D. +4 more
openaire +5 more sources
Eye, 2003 Neurotrophic keratopathy is a degenerative corneal disease induced by an impairment of trigeminal nerve. Impairment of loss of corneal sensory innervation is responsible for corneal epithelial defects, ulcer, and perforation. In the present report, we reviewed the pathogenesis, diagnosis, and therapeutic aspects of this disease. An accurate history and
Bonini, S +3 more
openaire +2 more sources
Acanthamoeba genotype T4 from the UK and Iran and isolation of the T2 genotype from clinical isolates [PDF]
, 2005 The majority of the keratitis-causing Acanthamoeba isolates are genotype T4. In an attempt to determine whether predominance of T4 isolates in Acanthamoeba keratitis is due to greater virulence or greater prevalence of this genotype, Acanthamoeba ...
Alsam +21 more
core +1 more source
Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease. [PDF]
, 2013 Dry eye disease can cause ocular surface inflammation that disrupts the corneal epithelial barrier. While dry eye patients are known to have an increased risk of corneal infection, it is not known whether there is a direct causal relationship between ...
Evans, David +4 more
core +12 more sources
Neurotrophic factors and corneal nerve regeneration [PDF]
, 2017 The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination.
Lambiase, Alessandro, Sacchetti, Marta
core +2 more sources
Herpes simplex keratitis: Challenges in diagnosis and clinical management [PDF]
, 2017 Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a ...
Azher, Tayaba N +4 more
core +3 more sources
Microorganisms and Common Ophthalmic Diseases [PDF]
, 2017 The human eye is in constant contact to environmental conditions that increase its likelihood in being exposed to a multitude of pathogens. Studies have revealed that the normal microbial flora found around the ocular area contribute to the well-being of
Su CW, Tighe S
core +1 more source
Empirical treatment of bacterial keratitis: an international survey of corneal specialists. [PDF]
, 2017 Background/aimsNew antibiotic agents and changing susceptibility patterns may have changed the empirical treatment of bacterial keratitis. Our objective in this study was to survey cornea specialists' practice patterns in the initial treatment of ...
Austin, Ariana +5 more
core +2 more sources
Fungal Keratitis Associated with Viral Keratitis
Chinese Medical Journal, 2015 Microbial keratitis caused by more than one microorganism is rare. It may occur as a coinfection or as a secondary infection superimposed with an existent microorganism.[1] Both infectious and immune mechanisms are implicated in microbial keratitis. Herein, we report an unusual clinical case of viral and fungal mixed infection. Written informed consent
Ting-Ting Lin +6 more
openaire +4 more sources