Results 91 to 100 of about 23,168 (223)
Inositol pyrophosphate kinases in health and disease
In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing +6 more
wiley +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Purpose. To assess an association of markers near the COL5A1 gene and in its intron with keratoconus. To study the relationship between the presence of marker alleles and the level of expression of the COL5A1 gene in the cornea of patients with ...
L. O. Skorodumova +7 more
doaj +1 more source
A Review of Artificial Intelligence in Ophthalmology: Key Aspects, Challenges, and Future Directions
ABSTRACT Artificial intelligence (AI) is increasingly reshaping ophthalmology because the specialty depends heavily on structured imaging, quantitative measurements, and repeatable diagnostic workflows. This review provides a clinically grounded and translationally oriented synthesis of AI in ophthalmology, covering methodological foundations ...
Partha Pratim Ray
wiley +1 more source
ABSTRACT Background Keratoconus is a progressive corneal ectatic disorder. Accelerated transepithelial corneal cross‐linking (ATE‐CXL) aims to halt progression while preserving the epithelium, but evidence on its 12‐month efficacy requires further evaluation.
Rafea Allawi Fayyadh +4 more
wiley +1 more source
Mean posterior corneal power and astigmatism in normal versus keratoconic eyes
Purpose: To compare mean posterior corneal power and astigmatism in normal versus keratoconus affected eyes and determine the optimal cut-off points to maximize sensitivity and specificity in discriminating keratoconus from normal corneas.
Sepehr Feizi +5 more
doaj +1 more source
Optical Coherence Tomography Pachymetry Mapping in Diagnosis of Keratoconus
Purpose: To evaluate abnormal corneal thinning using optical coherence tomography (OCT) pachymetry mapping in keratoconus patients. Material and Method: In this prospective study, 57 eyes of 33 keratoconus patients and 50 eyes of 25 control subjects ...
Canan Gürdal +9 more
core +1 more source
Keratoconus: current perspectives
Jayesh Vazirani, Sayan BasuCornea and Anterior Segment Services, LV Prasad Eye Institute, Hyderabad, IndiaAbstract: Keratoconus is characterized by progressive corneal protrusion and thinning, leading to irregular astigmatism and impairment in visual ...
Vazirani J, Basu S
core
Keratoconus: An updated review
Received 19 August 2021, Revised 23 November 2021, Accepted 12 December 2021, Available online 4 January 2022, Version of Record 14 May 2022.Keratoconus is a bilateral and asymmetric disease which results in progressive thinning and steeping of the ...
Wolffsohn, James S. +5 more
core +1 more source
Xiaoyu Zhang,1– 3,* Lan Ding,1– 3,* Ling Sun,1– 3 Bingqing Sun,1– 3 Yangyi Huang,1– 3 Yishan Qian,1– 3,* Xingtao Zhou1– 3,* 1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, People’s ...
Sun L +6 more
core

