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The genetics of keratoconus

Clinical & Experimental Ophthalmology, 2001
ABSTRACTKeratoconus is a relatively common, bilateral, non‐ inflammatory corneal ectasia. The aetiology of this condition is probably multifactorial, or it represents the final common pathway for a variety of different pathological processes. Although a familial history is present only in a minority of cases, one of the major aetiological factors is ...
Simon J Dean   +2 more
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Keratoplasty for Keratoconus

Archives of Ophthalmology, 1959
For some time ophthalmologists have recognized that keratoplasty corrects keratoconus in a large percentage of cases. There is, however, some difference of opinion as to the optimal size of the grafts. Castroviejo 1 and others have suggested a large graft which replaces the entire conus, because the high corneal curvature remaining after a smaller ...
Gerald Swartz, R. Townley Paton
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Keratoconus

Cornea, 1988
Keratoconus is a bilateral disorder of corneal shape which may be sporadic or genetically determined. Early corneal thinning suggests that a functional loss of structural elements is a primary event in the disease. Tensile strength of the cornea is reduced and is expressed by signs of rupture and scarring in Bowman's layer, scarring in the substantia ...
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INTACS for Keratoconus

International Ophthalmology Clinics, 2006
The use of Intacs as a therapeutic modality in contact lens intolerant patients with mild to moderate keratoconus is increasingly gaining acceptance in the ophthalmic community.During the past year we have gleaned significant new information about patients who are appropriate candidates, the location and relative placement of segment sizes and long ...
openaire   +5 more sources

Intacs for keratoconus

Ophthalmology, 2003
To evaluate the efficacy and safety of placement of Intacs in subjects with keratoconus.Retrospective, nonrandomized comparative trial.Intrastromal corneal ring segment implantation.Seventy-four eyes of 50 subjects (41 male and 9 female) were evaluated. The mean age of subjects in the study was 35 years, ranging from 20 to 73 years. Twenty-six subjects
Brian S Boxer Wachler   +6 more
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The Genetics of Keratoconus

Seminars in Ophthalmology, 2013
Keratoconus is a bilateral, non-inflammatory corneal ectasia characterized by progressive conical thinning and protrusion of the cornea. Its etiology has long been believed to be multifactorial, with environmental, behavioral, and genetic factors all contributing to the disease process.
James Chodosh, Han-Ying Peggy Chang
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Keratoconus

Survey of Ophthalmology, 1998
Keratoconus is a bilateral noninflammatory corneal ectasia with an incidence of approximately 1 per 2,000 in the general population. It has well-described clinical signs, but early forms of the disease may go undetected unless the anterior corneal topography is studied. Early disease is now best detected with videokeratography.
openaire   +2 more sources

Keratoconus: A review

Contact Lens and Anterior Eye, 2010
Keratoconus is the most common primary ectasia. It usually occurs in the second decade of life and affects both genders and all ethnicities. The estimated prevalence in the general population is 54 per 100,000. Ocular signs and symptoms vary depending on disease severity. Early forms normally go unnoticed unless corneal topography is performed. Disease
James S. Wolffsohn   +2 more
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HLA and keratoconus

Tissue Antigens, 1983
HLA‐A and ‐B antigens were determined in 64 Caucasoid patients with keratoconus. A highly significant increase in the frequency of HLA‐B5 was found among the patients. Thus keratoconus is the third eye disease after recurrent herpetic keratitis and Behcet's disease showing an association with HLA‐B5.
D. L. Easty   +5 more
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Iridoschisis and Keratoconus

Cornea, 1994
We report herein a patient with iridoschisis and keratoconus. Since the posterior layers of the cornea and the iris stroma have a common embryological deviation, the combination of these two conditions suggests an inter-related pathogenesis. This case is similar to those of patients with progressive essential iris atrophy and keratoconus described by ...
Leon Lane, Richard A. Eiferman, Mark Law
openaire   +2 more sources

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