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Emollients, moisturizers, and keratolytic agents in psoriasis

Clinics in Dermatology, 2008
Emollients, moisturizers, and keratolytic agents are essential in the topical treatment of psoriasis. They are adjuvants for classic treatments and help to reduce the scale load of individual patients. The major role for emollients and moisturizers is the supportive role in normalizing hyperproliferation, differentiation, and apoptosis; furthermore ...
Enzo Berardesca, Joachim Fluhr
exaly   +3 more sources

The Effect of Keratolytic Agents on the Permeability of Three Imidazole Antimycotic Drugs Through the Human Nail

Drug Development and Industrial Pharmacy, 1998
The permeability of three imidazole antimycotics (miconazole nitrate, ketoconazole, and itraconazole) through the free edge of healthy human nail was evaluated in vitro using side-by-side diffusion cells. The influence of keratolytic substances (papain, urea, and salicylic acid) on the permeability of the antimycotics was also studied.
Yogeshvar Kalia   +2 more
exaly   +4 more sources

Onychomycosis Treated with Itraconazole or Griseofulvin Alone with and without a Topical Antimycotic or Keratolytic Agent

International Journal of Dermatology, 1991
Abstract: An open, comparative, randomized study was conducted using griseofulvin or itraconazole for the treatment of onychomycosis of the foot. Group I (45 patients) received itraconazole and Group II (45 patients) received griseofulvin. Each group was divided into three subgroups that received different topical treatment: antimycotic cream ...
R, Arenas, G, Fernández, L, Domínguez
exaly   +3 more sources

Use of a Keratolytic Agent With Occlusion for Topical Treatment of Hyperkeratotic Seborrheic Keratoses

SKINmed: Dermatology for the Clinician, 2008
Background . Seborrheic keratoses are the most common benign tumors in adults. Despite their negative cosmetic appearance, no topical treatment is commonly recommended for these lesions. Objective . Our objective was to assess whether clinical benefit could be achieved by using a keratolytic topical agent ...
Craig G, Burkhart, Craig N, Burkhart
openaire   +2 more sources

Effect of Metamorphed Keratolytic Agent on the Behavior of Imiquimod Loaded Hybrid Vesicles Containing Gel

Journal of Pharmaceutical Sciences, 2019
The cost, side effects, and patient compliance-related issues of topically effective imiquimod have prevented its widespread acceptance. The present work intends to evaluate the feasibility of overcoming the shortcomings of poorly soluble and skin-penetrating immunomodulator by using biocompatible keratolytic agent with drug-loaded hybrid vesicles ...
Mandeep, Sharma   +4 more
openaire   +2 more sources

Development and In-vitro Characterization of Fish Oil Oleogels Containing Benzoyl Peroxide and Salicylic Acid as Keratolytic Agents

Drug Research, 2013
Topical keratolytic agents such as benzoyl peroxide (BP) and salicylic acid (SA) are one of the common treatments for inflammatory skin diseases. However, the amount of drug delivery through the skin is limited due to the stratum corneum. The purposes of this study were to investigate the ability of fish oil to act as penetration enhancer for topical ...
K, Rehman, C M, Tan, M H, Zulfakar
openaire   +2 more sources

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