Results 141 to 150 of about 2,268 (155)

Emollients, moisturizers, and keratolytic agents in psoriasis

open access: closedClinics in Dermatology, 2008
Emollients, moisturizers, and keratolytic agents are essential in the topical treatment of psoriasis. They are adjuvants for classic treatments and help to reduce the scale load of individual patients. The major role for emollients and moisturizers is the supportive role in normalizing hyperproliferation, differentiation, and apoptosis; furthermore ...
Joachim W. Fluhr   +2 more
openaire   +4 more sources

Use of a Keratolytic Agent With Occlusion for Topical Treatment of Hyperkeratotic Seborrheic Keratoses

open access: closedSKINmed: Dermatology for the Clinician, 2008
Background . Seborrheic keratoses are the most common benign tumors in adults. Despite their negative cosmetic appearance, no topical treatment is commonly recommended for these lesions. Objective . Our objective was to assess whether clinical benefit could be achieved by using a keratolytic topical agent ...
Craig G. Burkhart, Craig N. Burkhart
openaire   +4 more sources

Onychomycosis Treated with Itraconazole or Griseofulvin Alone with and without a Topical Antimycotic or Keratolytic Agent

open access: closedInternational Journal of Dermatology, 1991
Abstract: An open, comparative, randomized study was conducted using griseofulvin or itraconazole for the treatment of onychomycosis of the foot. Group I (45 patients) received itraconazole and Group II (45 patients) received griseofulvin. Each group was divided into three subgroups that received different topical treatment: antimycotic cream ...
Fernández G, Domínguez L, Arenas R
openaire   +4 more sources

Effect of Metamorphed Keratolytic Agent on the Behavior of Imiquimod Loaded Hybrid Vesicles Containing Gel

open access: closedJournal of Pharmaceutical Sciences, 2019
The cost, side effects, and patient compliance-related issues of topically effective imiquimod have prevented its widespread acceptance. The present work intends to evaluate the feasibility of overcoming the shortcomings of poorly soluble and skin-penetrating immunomodulator by using biocompatible keratolytic agent with drug-loaded hybrid vesicles ...
Gajanand Sharma   +4 more
openaire   +4 more sources

The Effect of Keratolytic Agents on the Permeability of Three Imidazole Antimycotic Drugs Through the Human Nail

open access: closedDrug Development and Industrial Pharmacy, 1998
The permeability of three imidazole antimycotics (miconazole nitrate, ketoconazole, and itraconazole) through the free edge of healthy human nail was evaluated in vitro using side-by-side diffusion cells. The influence of keratolytic substances (papain, urea, and salicylic acid) on the permeability of the antimycotics was also studied.
Quintanar-Guerrero, D   +4 more
openaire   +4 more sources

Photodynamic therapy of acne vulgaris using 5‐aminolevulinic acid 0.5% liposomal spray and intense pulsed light in combination with topical keratolytic agents

open access: closedJournal of the European Academy of Dermatology and Venereology, 2010
AbstractBackground  Increasing antibiotic resistance of Propionibacterium acnes and growing awareness on the side effects of topical and systemic drugs in the treatment of acne vulgaris by physicians and patients have paved the way for a search into new efficacious and safe treatment modalities such as photodynamic therapy (PDT).
J de Leeuw   +3 more
openaire   +5 more sources

Development and In-vitro Characterization of Fish Oil Oleogels Containing Benzoyl Peroxide and Salicylic Acid as Keratolytic Agents

open access: closedDrug Research, 2013
Topical keratolytic agents such as benzoyl peroxide (BP) and salicylic acid (SA) are one of the common treatments for inflammatory skin diseases. However, the amount of drug delivery through the skin is limited due to the stratum corneum. The purposes of this study were to investigate the ability of fish oil to act as penetration enhancer for topical ...
Mohd Hanif Zulfakar   +2 more
openaire   +4 more sources

Evaluation of a urea/lactic acid-based topical keratolytic agent (ULABTKA) for prevention of capecitabine-induced hand and foot syndrome (HFS): NCCTG trial N05C5.

open access: closedJournal of Clinical Oncology, 2010
9017 Background: HFS is a dose-limiting toxicity of capecitabine, occurring in 43-71% of patients. No effective preventative treatment has been definitively demonstrated.
John W. Kugler   +9 more
openaire   +3 more sources

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