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Archives of Otolaryngology - Head and Neck Surgery, 1950
The most dreaded late complication of hemorrhagic disease of the newborn (erythroblastosis fetalis) is kernicterus. This is manifest pathologically as more or less symmetrical yellow pigmentation of the basal ganglions and certain brain nuclei associated with severe cell damage and clinically as motor abnormalities and varying degrees of permanent ...
Roy N. Barnett, Clifford F. Ryder
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The most dreaded late complication of hemorrhagic disease of the newborn (erythroblastosis fetalis) is kernicterus. This is manifest pathologically as more or less symmetrical yellow pigmentation of the basal ganglions and certain brain nuclei associated with severe cell damage and clinically as motor abnormalities and varying degrees of permanent ...
Roy N. Barnett, Clifford F. Ryder
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Australasian Radiology, 2003
SUMMARYKernicterus (bilirubin encephalopathy) is a disease entity with a very high rate of mortality in neonates. The children who survive are left with neurological deficits such as choreoathetosis, sensorineural deafness and mental retardation. Magnetic resonance imaging of the brain in this condition has specfic findings which aid in the accurate ...
Ashish Chawla +3 more
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SUMMARYKernicterus (bilirubin encephalopathy) is a disease entity with a very high rate of mortality in neonates. The children who survive are left with neurological deficits such as choreoathetosis, sensorineural deafness and mental retardation. Magnetic resonance imaging of the brain in this condition has specfic findings which aid in the accurate ...
Ashish Chawla +3 more
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Annals of Neurology, 1986
AbstractA 43‐year‐old woman was initially seen because of icterus. Clinical investigations revealed severe hepatic damage probably due to non‐A, non‐B hepatitis. She was treated with extracorporeal charcoal‐column perfusion but died two weeks later in a hepatic coma. At autopsy, the brain showed kernicterus with typical discoloration of the hippocampus,
Marco Waser, Paul Kleihues, Paul Frick
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AbstractA 43‐year‐old woman was initially seen because of icterus. Clinical investigations revealed severe hepatic damage probably due to non‐A, non‐B hepatitis. She was treated with extracorporeal charcoal‐column perfusion but died two weeks later in a hepatic coma. At autopsy, the brain showed kernicterus with typical discoloration of the hippocampus,
Marco Waser, Paul Kleihues, Paul Frick
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Pediatrics, 1983
To the Editor.— Turkel and associates1 postulate that gross bilirubin staining of newborn infants' brains, as observed at autopsy, is only incidental and does not correlate with specific microscopic changes as described with "true kernicterus": microscopic study of brain sections from 32 infants in whom the typical gross bilirubin ...
M, Ahdab-Barmada, J, Moossy
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To the Editor.— Turkel and associates1 postulate that gross bilirubin staining of newborn infants' brains, as observed at autopsy, is only incidental and does not correlate with specific microscopic changes as described with "true kernicterus": microscopic study of brain sections from 32 infants in whom the typical gross bilirubin ...
M, Ahdab-Barmada, J, Moossy
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Controversial Topics in Kernicterus
Clinics in Perinatology, 1988The physiology of the blood-brain barrier and its disruption by a variety of pathophysiologic processes in the development of experimental and clinical kernicterus are reviewed. The use of currently available methods for measuring free and bound bilirubin in developing strategies for the prevention of kernicterus and more subtle sequelae of ...
Philip Roth, Richard A. Polin
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NEONATAL JAUNDICE AND KERNICTERUS
Archives of Pediatrics & Adolescent Medicine, 1954THE PURPOSE of this paper is to examine critically the available data bearing on the pathogenesis of kernicterus. During the past decade and a half, knowledge of the etiologic importance of incompatibility between the blood groups of the fetus and the mother has expanded rapidly.
M. Furuta +3 more
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Journal of Paediatrics and Child Health, 1985
ABSTRACTKernicterus is a frequent occurrence in Chinese term infants. In a previous study, the mean level of serum bilirubin of 152 kernicteric infants was 35.4 mg/dl (605.3 μmol/l) and the range was 22.3‐50 mg/dl. More recently, three further term infants developed kernicterus and one exhibited bilirubin level of only 23.3 mg/dl.
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ABSTRACTKernicterus is a frequent occurrence in Chinese term infants. In a previous study, the mean level of serum bilirubin of 152 kernicteric infants was 35.4 mg/dl (605.3 μmol/l) and the range was 22.3‐50 mg/dl. More recently, three further term infants developed kernicterus and one exhibited bilirubin level of only 23.3 mg/dl.
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Veterinary Pathology, 2007
A 7-year-old, spayed female, Wheaton terrier dog was icteric, lethargic, and anorexic with increased activity of hepatocellular and cholestatic liver enzymes and an extreme hyperbilirubinemia level of 609 μmol/L (reference interval: 1.0–4.0 μmol/L). Necropsy findings included profound icterus and red and yellow mottling of the liver.
C. R. Sangster +4 more
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A 7-year-old, spayed female, Wheaton terrier dog was icteric, lethargic, and anorexic with increased activity of hepatocellular and cholestatic liver enzymes and an extreme hyperbilirubinemia level of 609 μmol/L (reference interval: 1.0–4.0 μmol/L). Necropsy findings included profound icterus and red and yellow mottling of the liver.
C. R. Sangster +4 more
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Neonatal Jaundice and Kernicterus
Pediatrics, 2001* Abbreviations: AAP = : American Academy of Pediatrics • G-6-PD = : glucose-6-phosphate dehydrogenase The American Academy of Pediatrics (AAP) Subcommittee on Hyperbilirubinemia is currently revising the practice parameter (guidelines) on neonatal hyperbilirubinemia published in October 1994.1 Although this revision is in ...
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Kernicterus in erythroblastosis fetalis
The Journal of Pediatrics, 1946Summary In a series of seventy-two cases of erythroblastosis fetalis there were twenty-fivedeaths with twenty-one autopsies. Four of the surviving patients have mental retardation. An unfavorable outcome was associated with the clinical or pathologic signs of kernicterus in twenty cases.
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