Results 341 to 350 of about 345,134 (373)

A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder.

American Journal of Psychiatry, 2021
OBJECTIVE Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for which available pharmacotherapies have limited efficacy. The authors' previous proof-of-concept randomized controlled trial of single-dose intravenous ketamine ...
A. Feder, S. Costi, S. Rutter, A. Collins, Usha Govindarajulu, M. Jha, S. Horn, Marin M. Kautz, M. Corniquel, K. Collins, L. Bevilacqua, Andrew Glasgow, Jess Brallier, R. Pietrzak, J. Murrough, D. Charney   +15 more
semanticscholar   +1 more source

Ketamine

Reactions Weekly, 2008
There are two optical isomers of the 2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone ketamine: S(+) ketamine and R(-) ketamine. Effects of this drug are mediated by N-methyl-d-aspartate (NMDA), opioid, muscarinic and different voltage-gated receptors.
B, Sinner, B M, Graf
openaire   +3 more sources

Long-term safety of ketamine and esketamine in treatment of depression

Expert Opinion on Drug Safety, 2022
Introduction Ketamine can produce rapid-acting antidepressant effects. Esketamine (Spravato), the S-enantiomer of racemic ketamine, was approved by the FDA for treatment-resistant depression in 2019.
Sina Nikayin, Eva L. Murphy, J. Krystal, S. Wilkinson   +3 more
semanticscholar   +1 more source

Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial.

American Journal of Psychiatry, 2021
OBJECTIVE Adolescent depression is prevalent and is associated with significant morbidity and mortality. Although intravenous ketamine has shown efficacy in adult treatment-resistant depression, its efficacy in pediatric populations is unknown.
J. Dwyer, A. Landeros-Weisenberger, Jessica A. Johnson, Amalia Londoño Tobón, José M. Flores, Madeeha Nasir, Kevin G. Couloures, G. Sanacora, M. Bloch   +8 more
semanticscholar   +1 more source

Anesthetic efficacy of ketamine, ketamine-tramadol and ketamine-ketorolac in chicks.

Iranian journal of veterinary research, 2019
Ketamine produces ordinary general anesthesia characterized by weak hypnosis and analgesia leading to complications during surgical operations.The aim of this study was to evaluate the combination of ketorolac or tramadol to enhance ketamine anesthesia in 7 to 20-day-old chicks and its feasibility and practical application for induction of general ...
Mousa, Y. J., Al-Zubaidy, M. H. I.
openaire   +2 more sources

Brain region–specific action of ketamine as a rapid antidepressant

Science
Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor (NMDAR), it was not clear whether there is a selective, primary site for
Min Chen, Shuangshuang Ma, Hanxiao Liu, Yiyan Dong, Jingxiang Tang, Zheyi Ni, Yi Tan, Chenchi Duan, Hui Li, Hefeng Huang, Yulong Li, Xiaohua Cao, Christopher J. Lingle, Yan Yang, Hailan Hu   +14 more
semanticscholar   +1 more source

Ketamine

Anaesthesia, 2007
Summary Ketamine is a very versatile inexpensive drug and plays an invaluable role in the developing world. In regions where access and funding for a wider range of drugs is problematic, its broad range of clinical applications is ideal.
openaire   +2 more sources

KETAMINE

The Lancet, 1970
J A, Gorringe, J, Danchin, D P, Evans, L J, Lees   +3 more
openaire   +5 more sources

Ketamine in neuropsychiatric disorders: an update

Neuropsychopharmacology, 2023
J. Johnston, B. Kadriu, C. Kraus, I. Henter, C. Zarate   +4 more
semanticscholar   +1 more source

Antidepressant effects of ketamine in depressed patients

Biological Psychiatry, 2000
R. Berman, A. Cappiello, A. Anand, D. Oren, G. Heninger, D. Charney, J. Krystal   +6 more
semanticscholar   +1 more source