Results 121 to 130 of about 1,079 (156)

Ketolides – The Modern Relatives of Macrolides

Clinical Pharmacokinetics, 2009
As with other widely used antibacterials, the abundant use of macrolides for management of ambulant infections has promoted emergence of resistance against them. Ketolides are structurally related to macrolides and were developed to overcome macrolide resistance, while sharing pharmacodynamic and pharmacokinetic characteristics.
Zeitlinger, M, Wagner, C C, Heinisch, B
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Review of Macrolides and Ketolides

Drugs, 2001
The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and was used primarily for respiratory and skin and soft tissue infections. Newer 14-, 15- and 16-membered ring macrolides such as clarithromycin and the azalide, azithromycin, have been developed to address the limitations of erythromycin.
G G, Zhanel, M, Dueck, D J, Hoban, L M, Vercaigne, J M, Embil, A S, Gin, J A, Karlowsky   +6 more
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Effects of Macrolides and Ketolides on Mycobacterial Infections

Current Pharmaceutical Design, 2004
New macrolides, such as clarithromycin and azithromycin, are active agents to Mycobacterium avium complex (MAC). Both clarithromycin and azithromycin are well-known for the ability to improve the prognosis of AIDS patients with disseminated MAC infection.
Luiz E, Bermudez, Yoshitaka, Yamazaki
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The Emerging New Generation of Antibiotic: Ketolides

Current Drug Targets - Infectious Disorders, 2001
The bacterial ribosome is a target for a variety of drug classes including macrolides. Macrolide antibiotics are primarily used for the treatment of respiratory tract infections. One of the most important features of the macrolide class is the excellent safety profile allowing the drug to be used broadly across all age groups.
P, Zhong, V, Shortridge
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ABT-773: a new ketolide antibiotic

Expert Opinion on Investigational Drugs, 2001
ABT-773 is a new semisynthetic derivative of erythromycin A, the ketolide class of broad spectrum antibacterial agents, in Phase II development by Abbott. With good broad spectrum activity against Gram-positive, some Gram-negative organisms and intracellular bacteria, ABT-773 is being developed as a respiratory agent. Structural changes in the ketolide
T J, Dougherty, J F, Barrett
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Telithromycin: An Oral Ketolide for Respiratory Infections

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2001
The ketolides represent a new subclass of antibiotics among the macrolide‐lincosamide‐streptogramin group. Telithromycin, the first ketolide to be awarded approvable status for clinical use, demonstrates in vitro activity against community‐acquired respiratory pathogens including penicillin‐ and erythromycin‐resistant Streptococcus pneumoniae.
D T, Bearden, M M, Neuhauser, K W, Garey
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Macrolide and Ketolide Resistance with Streptococcus pneumoniae

Medical Clinics of North America, 2006
Antimicrobial agents in the macrolide family have long been considered drugs of potential utility in the management of infections caused by Streptococcus pneumoniae. However, with the emergence of macrolide resistance, the clinical value of macrolides in pneumococcal infections is threatened.
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Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Todd C, Henninger, Xiaodong, Xu, Darren, Abbanat, Ellen Z, Baum, Barbara D, Foleno, Jamese J, Hilliard, Karen, Bush, Dennis J, Hlasta, Mark J, Macielag   +8 more
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[Telithromycin, first ketolide].

Revue medicale de Bruxelles, 2003
Telithromycine is the first ketolide on the market. Its characteristics are the two sites fixation on the bacterial ribosomia and and as a consequence a good activity on the majority of penicillin and macrolides resistant bacteria, included S. pneumonia and S. pyogenes.
Y, Van Laethem, J, Sternon
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[Macrolides, ketolides and streptogramins].

Enfermedades infecciosas y microbiologia clinica, 2003
Macrolides, ketolides and streptogramins are three families of antibiotics with different chemical structures, sharing the same mechanism of action. All three bind to distinct bases of the peptidyl transferase center of ARNr 23S. Their antibacterial spectrum practically overlaps, but dissimilarities in affinity and/or number of binding sites determine ...
José, Mensa, Elisa, García-Vázquez, Jordi, Vila   +2 more
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