Results 21 to 30 of about 1,299 (139)
Journal of Pharmacy & Pharmaceutical Sciences, 2020 Purpose: The preclinical pharmacokinetic and pharmacodynamic properties of a potent fluoroketolide RBx14255 against Streptococcus pneumoniae and Haemophilus influenzae was compared with telithromycin and human clinical dose was predicted for preclinical ...
Trdib Chaira +2 more
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Veterinary Record Open, Volume 7, Issue 1, 2020., 2020 Background Antimicrobial resistance is an increasing problem in human and veterinary medicine and is closely linked to the use of antimicrobials. The objective of this study was to describe antimicrobial prescriptions for selected canine diseases in Switzerland during 2016. Methods Dogs presented to two university hospitals and 14 private practices for
Bérénice Lutz +9 more
wiley +1 more source
Structure–activity relationships of ketolides vs. macrolides [PDF]
, 2001 Since their discovery, the macrolide antimicrobials have proved clinically valuable for the treatment of respiratory tract infections, offering coverage against a broad spectrum of pathogens and excellent tolerability.
Douthwaite, S.
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, 2014 Macrolides and ketolides are characterized by a very wide tissular distribution, which is related to their capacity to accumulate in the acidic compartments of the cells.
Van Bambeke, Françoise
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Ketolides--the modern relatives of macrolides : the pharmacokinetic perspective
, 2009 As with other widely used antibacterials, the abundant use of macrolides for management of ambulant infections has promoted emergence of resistance against them.
Heinisch, B, Zeitlinger, M, Wagner, C C
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Annals of Clinical Microbiology and Antimicrobials, 2004 Background In streptococci, three macrolide resistance determinants (erm(B), erm(TR) and mef(A)) have been found. In addition, certain mutations at the ribosomal 23S RNA can cause resistance to macrolides. Mutation at the position 2058 of the 23S rRNA of
Huovinen Pentti +2 more
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New therapeutic approaches for treatment of tularaemia: a review
Frontiers in Cellular and Infection Microbiology, 2014 Antibiotic treatment of tularaemia is based on a few drugs, including the fluoroquinolones, the tetracyclines and the aminoglycosides. Because no effective and safe vaccine is currently available, tularaemia prophylaxis following proven exposure to F ...
Sandrine eBOISSET +7 more
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Synthesis and Antibacterial Activity of Novel C12 Vinyl Ketolides
, 2016 A novel series of C12 vinyl erythromycin derivatives have been discovered which exhibit in vitro and in vivo potency against key respiratory pathogens. The C12 modification involves replacing the natural C12 methyl group in the erythromycin core with a ...
Alice C. Rico (2648317) +15 more
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Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides [PDF]
, 2015 A subset of Gram negative bacterial pathogens use a type 3 secretion system (T3SS) to open up a conduit into eukaryotic cells in order to inject effector proteins. These modulate pathways to enhance bacterial colonization.
Tahoun, Amin +11 more
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Synthesis and Structure−Activity Relationships of Novel 8a-Aza-8a-homoerythromycin A Ketolides
, 2016 A series of novel 6-O-substituted 8a-aza-8a-homoerythromycin A ketolides was synthesized and evaluated for in vitro antibacterial activity. Key strategic elements of the synthesis include the base-induced E−Z isomerization of 3-O-descladinosyl-6-O ...
Stjepan Mutak (1738849) +1 more
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