Results 121 to 130 of about 1,349 (178)

Six-Year Prescription Pattern of Antimicrobial Use in Cats at the Veterinary Teaching Hospital of the University of Pisa. [PDF]

Animals (Basel)
De Marchi L, Vernaccini M, Meucci V, Briganti A, Lippi I, Marchetti V, Intorre L.   +6 more
europepmc   +1 more source

Structural insights into context-specific inhibition of bacterial translation by macrolides. [PDF]

Nat Commun
Syroegin EA, Aleksandrova EV, Kruglov AA, Paranjpe MN, Svetlov MS, Polikanov YS.   +5 more
europepmc   +1 more source

Addressing urgent priorities in antibiotic development: insights from WHO 2023 antibacterial clinical pipeline analyses.

Lancet Microbe
Melchiorri D, Rocke T, Alm RA, Cameron AM, Gigante V.   +4 more
europepmc   +1 more source

Macrolides and Ketolides

Javier Garau
core   +1 more source

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance Studies of antibiotic resistance are usually initiated in earnest only after resistance has become established in clinical pathogens. Here, we forewarn of a resistance mechanism to the novel antibiotics ketolides, which are only coming into broad medical practice.
Stephen Douthwaite, David H Sherman, Alexander Mankin   +2 more
exaly   +14 more sources

Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site

Journal of Antimicrobial Chemotherapy, 2001
Ketolides are the most recent generation of antimicrobials derived from the 14-membered ring macrolide, erythromycin A. The main structural feature that differentiates ketolides from erythromycin is the keto group, which replaces the L-cladinose moiety ...
Stephen Douthwaite, W Scott Champney, W S Champney   +2 more
exaly   +2 more sources

Ketolides—telithromycin, an example of a new class of antibacterial agents [PDF]

Clinical Microbiology and Infection, 2000
Ketolides are new medicinal chemical entities. They are obtained by removing the 3-L-cladinose sugar moiety from erythronolide A and oxidation of the resulting 3-hydroxyl.
André Bryskier
exaly   +2 more sources

Ketolides in the treatment of community-acquired respiratory tract infections: A review [PDF]

Current Therapeutic Research, 2005
Background:The increasing prevalence of resistance to established antibiotics among key respiratory bacterial pathogens highlights a need for new antibacterial agents for the treatment of community-acquired respiratory tract infections (RTIs).
Martin S Lipsky
exaly   +2 more sources

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The Ketolides

Drugs, 2002
Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well as the D-desosamine sugar attached at position 5.
George G, Zhanel, Michael, Walters, Ayman, Noreddin, Lavern M, Vercaigne, Aleksandra, Wierzbowski, John M, Embil, Alfred S, Gin, Stephen, Douthwaite, Daryl J, Hoban   +8 more
openaire   +4 more sources

Telithromycin: The First of the Ketolides

Annals of Pharmacotherapy, 2002
OBJECTIVE: To review the chemistry, spectrum of activity, pharmacology, clinical efficacy, and safety of telithromycin. DATA SOURCES: A MEDLINE search from 1966 to December 2000 was performed via OVID and PubMed using the following ...
Christopher S, Shain, Guy W, Amsden
openaire   +2 more sources