Results 11 to 20 of about 1,346 (179)
Emerging Treatment Options for Infections by Multidrug-Resistant Gram-Positive Microorganisms
Microorganisms, 2020 Antimicrobial agents are currently the mainstay of treatment for bacterial infections worldwide. However, due to the increased use of antimicrobials in both human and animal medicine, pathogens have now evolved to possess high levels of multi-drug ...
Despoina Koulenti +7 more
doaj +1 more source
Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
Nature Communications, 2021 Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome.
Bertrand Beckert +13 more
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Scaffold Modifications in Erythromycin Macrolide Antibiotics. A Chemical Minireview
Molecules, 2020 Clarithromycin and congeners are important antibacterial members of the erythromycin A 14-membered macrocyclic lactone family. The macrolide scaffold consists of a multifunctional core that carries both chemically reactive and non-reactive substituents ...
Kjell Undheim
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Ceftiofur use and antimicrobial stewardship in the horse
Equine Veterinary Journal, Volume 55, Issue 6, Page 944-961, November 2023., 2023 Abstract Equine practitioners require recommendations that support antimicrobial stewardship and avoid generating resistance to medically important antibiotics. This review examines current inadequacies in antimicrobial stewardship standards within the veterinary community, related to antimicrobial categorisation and prescribing practices.
Clare A. Ryan +2 more
wiley +1 more source
Antimicrobial prescribing and antimicrobial resistance surveillance in equine practice
Equine Veterinary Journal, Volume 55, Issue 3, Page 494-505, May 2023., 2023 Abstract Background Antimicrobial resistance (AMR) is an increasingly serious threat to human and animal health, therefore responsible use of antimicrobials in equine practice is vital. There is a need to have accurate, up to date data on antimicrobial prescribing in equine practice in the UK.
Amie Wilson +4 more
wiley +1 more source
Antibiotics, 2021 Lefamulin is the first of the pleuromutilin class of antimicrobials to be available for therapeutic use in humans. Minimum inhibitory concentrations of lefamulin were determined by microbroth dilution for 90 characterised clinical isolates (25 Ureaplasma
Oliver Spiller-Boulter +5 more
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A framework for evaluation of on‐farm mastitis diagnostics in Australia
Australian Veterinary Journal, Volume 101, Issue 4, Page 142-152, April 2023., 2023 Numerous culture‐based diagnostics are available on the Australian and international markets for on‐farm detection of bacterial pathogens in milk. Use of such diagnostics may provide an opportunity to improve the prudent use of antimicrobials in udder health management. Farms are low‐resource settings in terms of diagnostic microbiology capacity.
RN Zadoks +5 more
wiley +1 more source
From gut to mud: dissemination of antimicrobial resistance between animal and agricultural niches
Environmental Microbiology, Volume 24, Issue 8, Page 3290-3306, August 2022., 2022 Summary With increasing reports on antimicrobial resistance (AMR) in humans, animals and the environment, we are at risk of returning to a pre‐antibiotic era. Therefore, AMR is recognized as one of the major global health threats of this century. Antibiotics are used extensively in farming systems to treat and prevent infections in food animals or to ...
Niti B. Jadeja, Anja Worrich
wiley +1 more source
Nature Communications, 2023 The ever-growing rise of antibiotic resistance among bacterial pathogens is one of the top healthcare threats today. Although combination antibiotic therapies represent a potential approach to more efficiently combat infections caused by susceptible and ...
Chih-Wei Chen +7 more
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Journal of Veterinary Pharmacology and Therapeutics, Volume 44, Issue 2, Page 172-200, March 2021., 2021 Abstract Pharmacokinetic/pharmacodynamic (PK/PD) modelling is the initial step in the semi‐mechanistic approach for optimizing dosage regimens for systemically acting antimicrobial drugs (AMDs). Numerical values of PK/PD indices are used to predict dose and dosing interval on a rational basis followed by confirmation in clinical trials. The value of PK/
Pierre‐Louis Toutain +5 more
wiley +1 more source