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Antimicrobial-Resistant Streptococcus pneumoniae in Canadian Hospitals: Results from the 2007 CANWARD Study

Canadian Journal of Infectious Diseases and Medical Microbiology, 2009
BACKGROUND: The Canadian Ward Surveillance Study (CANWARD 2007) tested isolates collected from January to December 2007 from 12 Canadian hospitals to a range of antimicrobial agents.
Aleksandra K Wierzbowski +5 more
doaj +1 more source

Synthesis and Structure–Activity Relationships of α‑Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics

, 2016
An efficient synthesis of α-amino-γ-lactone ketolide (3) was developed, which provided a versatile intermediate for the incorporation of a variety of aryl and heteroaryl groups onto the C-21 position of clarithromycin via HBTU-mediated amidation.
Daniele Andreotti (1738852) +8 more
core +1 more source

Synthesis and Antibacterial Activity of Ketolides (6-O-Methyl-3-oxoerythromycin Derivatives): A New Class of Antibacterials Highly Potent Against Macrolide-Resistant and -Susceptible Respiratory Pathogens^†

, 2016
In the search for new antibiotics active against macrolide-resistant pneumococci and Haemophilus influenzae, we synthesized a new class of 3-oxo-6-O-methylerythromycin derivatives, so-called “ketolides”. A keto function was introduced in position 3 after
Arlette Dussarat (3022353) +14 more
core +1 more source

Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics

, 2021
Ketolides, characterized by possessing a 3-keto group in place of the l-cladinose moiety of erythromycin A, are the recent generation of antimicrobials derived semi-synthetically from the 14-membered ring macrolide erythromycin A.
윤여준
core +1 more source

Erythromycin-induced insensitivity of coagulase-negative staphylococci to telithromycin

Current Issues in Pharmacy and Medical Sciences
Telithromycin represents a new group of antibiotics, called ketolides, belonging to the same family as MLSB (macrolide, lincosamide, streptogramin B) antibiotics.
Marek Juda +5 more
doaj

Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management

Journal of Pain Research, 2017
Xiu-qin Feng,1 Ling-ling Zhu,2 Quan Zhou3 1Nursing Administration Office, Division of Nursing, 2VIP Care Ward, Division of Nursing, 3Department of Pharmacy, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang ...
Feng XQ, Zhu LL, Zhou Q
doaj

Assessing antimicrobial resistance in Campylobacter jejuni and Campylobacter coli and its association with antimicrobial use in Canadian turkey flocks. [PDF]

Epidemiol Infect, 2023
Shrestha RD, Agunos A, Gow SP, Varga C.
europepmc +1 more source

The In Vitro Antimicrobial Susceptibility of Borrelia burgdorferi sensu lato: Shedding Light on the Known Unknowns. [PDF]

Pathogens, 2023
Hunfeld KP, Kraiczy P, Norris DE, Lohr B. +3 more
europepmc +1 more source

QUINUPRISTIN/DALFOPRISTIN (Q/D) FOR TREATMENT OF SEVERE MULTIDRUG RESISTANT STAPHYLOCOCCUS INFECTION.

, 1998
The fourth International Conference on the Macrolides, Azalides, Streptogramins & Ketolides.
L. MINOLI +5 more
core

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides.

, 2016
Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, in part because of the low propensity of these drugs to trigger the expression of resistance genes.
DH Sherman (7940990) +7 more
core

medicine