Results 121 to 130 of about 1,299 (139)

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2015
Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, in part because of the low propensity of these drugs to trigger the expression of resistance genes.
Stephen Douthwaite, David H Sherman, Alexander Mankin   +2 more
exaly   +10 more sources

Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site

Journal of Antimicrobial Chemotherapy, 2001
Ketolides are the most recent generation of antimicrobials derived from the 14-membered ring macrolide, erythromycin A. The main structural feature that differentiates ketolides from erythromycin is the keto group, which replaces the L-cladinose moiety ...
Stephen Douthwaite, W Scott Champney, W S Champney   +2 more
exaly   +2 more sources

Ketolides—telithromycin, an example of a new class of antibacterial agents [PDF]

Clinical Microbiology and Infection, 2000
Ketolides are new medicinal chemical entities. They are obtained by removing the 3-L-cladinose sugar moiety from erythronolide A and oxidation of the resulting 3-hydroxyl.
André Bryskier
exaly   +2 more sources

Ketolides in the treatment of community-acquired respiratory tract infections: A review [PDF]

Current Therapeutic Research, 2005
Background:The increasing prevalence of resistance to established antibiotics among key respiratory bacterial pathogens highlights a need for new antibacterial agents for the treatment of community-acquired respiratory tract infections (RTIs).
Martin S Lipsky
exaly   +2 more sources

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Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides

Bioorganic and Medicinal Chemistry Letters, 2004
Angela M Nilius, Stevan W Djuric, Zhenkun Ma   +2 more
exaly   +2 more sources

A journey across the sequential development of macrolides and ketolides related to erythromycin

Tetrahedron, 2006
Sarbani Pal
exaly  

New research in macrolides and ketolides since 1997

Expert Opinion on Investigational Drugs, 1999
A Bryskier
exaly  

Structural Basis for the Antibiotic Activity of Ketolides and Azalides

Structure, 2003
Raz Zarivach, François Franceschi
exaly  

Synthesis of novel 5-O-(6′-O-modified)-desosamine 14-membered ketolides

Chinese Chemical Letters, 2019
Zhehui Zhao, Pingsheng Lei
exaly  

An efficient method to synthesize novel 5-O-(6′-modified)-mycaminose 14-membered ketolides

Tetrahedron, 2016
Zhehui Zhao, Pingsheng Lei
exaly