Results 21 to 30 of about 2,042 (99)

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, Volume 13, Issue 41, 22 July 2026.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Protein hydrolysates in cell culture: Toward multi‐omics characterization

Biotechnology Progress, Volume 42, Issue 4, July/August 2026.
While protein hydrolysates are widely used in cell culture applications, they remain undefined and variable products. Multi‐omic characterization evaluating composition and function can transition hydrolysates toward semi‐defined media components.
Michelle Combe, Brandon M. Wrage, Angel Varela‐Rohena, Stanislav Sokolenko   +3 more
wiley   +1 more source

Coenzyme Acceptance in Ene‐Reductases From Herbaspirillum seropedicae

ChemistryEurope, Volume 4, Issue 7, July 2026.
Ene‐reductases HSI and HSII from the beta‐proteobacterium Herbaspirillum seropedicae show promiscuity towards the coenzymes NADH and NADPH and efficiently reduce maleimides. Ancestral sequence reconstruction, kinetic characterisation and structural analysis suggest that oligomerisation contributes to the evolution of coenzyme acceptance. Ene‐reductases
Karishma Shah, Silvia Wallner, Aleksandar Bijelic, André Pick, Peter Macheroux, Robert Kourist, Daniel Kracher   +6 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

A high-sensitivity strategy to screen NAD(P)H-dependent reductase activity by coupled enzyme cascade. [PDF]

J Biol Chem
Ghosh T, Sicheri J, Kwan DH.
europepmc   +1 more source

Identification of the C9-hydrogenase for 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid (9,17-DOHNA) and the 7α-dehydratase essential for initiating β-oxidation of the B-, C-, and D-rings in steroid degradation by <i>Comamonas testosteroni</i> TA441. [PDF]

Appl Environ Microbiol
Horinouchi M.
europepmc   +1 more source

Studies of α',β'-Epoxyketone Synthesis by Small-Molecule Flavins and Flavoenzymes. [PDF]

Angew Chem Int Ed Engl
Walter A, Kuttenlochner W, Eisenreich W, Yao C, Groll M, Storch G.   +5 more
europepmc   +1 more source

Toward Sustainability: Intensification of Light-Driven Whole Cell Biocatalysis. [PDF]

Chembiochem
Malihan-Yap L, Domínguez de Maria P, Kourist R.   +2 more
europepmc   +1 more source

Engineered Flavin-Dependent Halogenases Catalyze C-C Bond Formation via Enantioselective Semipinacol Rearrangement. [PDF]

J Am Chem Soc
Shen X, Gupta P, Gandhi P, Ramirez I, Mondal D, Lewis JC.   +5 more
europepmc   +1 more source

Cyanobacteria-Mediated Light-Driven Biotransformation: The Current Status and Perspectives. [PDF]

ACS Omega, 2023
Cheng J, Zhang C, Zhang K, Li J, Hou Y, Xin J, Sun Y, Xu C, Xu W.   +8 more
europepmc   +1 more source