Results 201 to 210 of about 5,861,224 (248)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Bioinformatics Identification and Functional Analysis of Key Genes of Nucleotide Metabolism in Oral Squamous Cell Carcinoma. [PDF]

Oral Health Prev Dent
Wei F, Fan H.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Life table of Myrmeleon fuscus Yang (Neuroptera: Myrmeleontidae) fed on different natural diets. [PDF]

J Insect Sci
Zhang T, Li X, Liu M, Zhang L, Wang M, Li Y, Shen Z, Zheng L, Mao J.   +8 more
europepmc   +1 more source

Communication is key

Mens Sana Monographs, 2013
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Defining Nonsuicidal Self-Injury in Autistic People: A Framework for Assessment Using Key Elements to Aid in Characterization. [PDF]

Autism Adulthood
Antezana L, Conner CM, Feldman J, Manna LL, Ionadi A, Su DJ, Eldeeb S, Gastgeb H, Sivathasan S, Northrup JB, Beck KB, Scott LN, Mazefsky CA.   +12 more
europepmc   +1 more source

Dual-omics analysis of key biomarkers in T cell ubiquitination of rheumatoid arthritis blood and synovial tissue, validated by two-sample Mendelian randomization and qPCR. [PDF]

Front Immunol
He D, Zhao H, Meng J.
europepmc   +1 more source

A pH-stable dynamic DNA nanomachine with controllable conformational switching. [PDF]

Nanoscale Adv
Lin L, Liang K, Gao X, Li J, Guo L, Jiao K, Wang L.   +6 more
europepmc   +1 more source

China's petrochemical plants' CO₂ emissions and high-impact contributors for carbon-neutrality production. [PDF]

Sci Adv
Chen X, Lei T, Zhao W, Ma S, Lai C, Guan D.   +5 more
europepmc   +1 more source