Results 241 to 250 of about 6,156,502 (298)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The role of positive parental involvement in preventing drug and substance misuse among young people in Zimbabwe: a qualitative study. [PDF]

BMJ Open
Kusemwa C, Kabonga I, Mazuruse I, Musara E.   +3 more
europepmc   +1 more source

Decision Revise: Sex chromosomes and chromosomal rearrangements are key to behavioural sexual isolation in Jaera albifrons marine isopods. Round#1

Thomas Lenormand
openalex   +1 more source

Communication is key

Mens Sana Monographs, 2013
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Publisher Correction: Realization of a Dirac-vortex topological photonic crystal fiber. [PDF]

Nat Commun
Niu Q, Yan B, Shen L, Lin H, Zhang X, Wan Z, Xu M, Zhang H, Luo J, Zhang L, Shum PP, Gao Z, Wang J.   +12 more
europepmc   +1 more source

Summary of the SECCEE project's foresight and key findings - Leaflet - RO

Confederation of Hungarian Employers and Industrialists - MGYOSZ-BusinessHungary
openalex   +1 more source

Transforming free-text coronary angiography reports into structured, analyzable data using large language models. [PDF]

Sci Rep
Song JW, Jang JY, Kim H, Ko YG, You SC.
europepmc   +1 more source