Results 141 to 150 of about 2,769,384 (254)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Mapping assays to the key characteristics of carcinogens to support decision-making. [PDF]

Database (Oxford)
Rigutto G, McHale CM, Singam ERA, Rana I, Zhang L, Smith MT.   +5 more
europepmc   +1 more source

Invited Perspective: Key Characteristics as a Starting Point for Improved Hazard Identification of Immunotoxic Agents. [PDF]

Environ Health Perspect, 2022
DeWitt JC, Walker LM.
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Multidisciplinary stakeholder-informed identification of key characteristics for implementation of workplace genetic testing. [PDF]

HGG Adv
Charnysh E, Sanghavi K, Ryan KA, Vogle A, Truhlar A, Pal S, Reader JM, Roberts JS, Lee C, Prince AER, Feero WG, INSIGHT @ Work Consortium.   +11 more
europepmc   +1 more source

Key characteristics impacting survival of COVID-19 extracorporeal membrane oxygenation. [PDF]

Crit Care, 2022
Herrmann J, Lotz C, Karagiannidis C, Weber-Carstens S, Kluge S, Putensen C, Wehrfritz A, Schmidt K, Ellerkmann RK, Oswald D, Lotz G, Zotzmann V, Moerer O, Kühn C, Kochanek M, Muellenbach R, Gaertner M, Fichtner F, Brettner F, Findeisen M, Heim M, Lahmer T, Rosenow F, Haake N, Lepper PM, Rosenberger P, Braune S, Kohls M, Heuschmann P, Meybohm P, German ECMO COVID Study Group.   +30 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Implementation of opportunistic salpingectomy for ovarian cancer prevention: Analyzing clinical practice and key characteristics. [PDF]

Acta Obstet Gynecol Scand
Fisch C, Gelderblom ME, Slangen B, Oei ALM, van Ginkel AA, Ngo H, de Hullu J, Piek J, Hermens R.   +8 more
europepmc   +1 more source

Linking Pollutants and Therapeutics to Heart Health: Key Characteristics of Cardiovascular Toxicants. [PDF]

Environ Health Perspect, 2021
Schmidt S.
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source