Results 11 to 20 of about 2,769,384 (254)

The key characteristics concept. [PDF]

Curr Opin Toxicol
In evaluating whether a chemical can cause cancer or another adverse outcome, three lines of evidence are typically considered: epidemiology, animal bioassays and mechanistic evidence. The key characteristics (KCs) form the basis of a uniform approach for searching, organizing, and evaluating mechanistic evidence to support hazard identification.
Smith MT.
europepmc   +3 more sources

Key Characteristics of Cardiovascular Toxicants. [PDF]

Environ Health Perspect, 2021
The concept of chemical agents having properties that confer potential hazard called key characteristics (KCs) was first developed to identify carcinogenic hazards. Identification of KCs of cardiovascular (CV) toxicants could facilitate the systematic assessment of CV hazards and understanding of assay and data gaps associated with current approaches ...
Lind L, Araujo JA, Barchowsky A, Belcher S, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, Smith MT.   +18 more
europepmc   +7 more sources

Consensus on the key characteristics of metabolism disruptors. [PDF]

Nat Rev Endocrinol
Metabolism-disrupting agents (MDAs) are chemical, infectious or physical agents that increase the risk of metabolic disorders. Examples include pharmaceuticals, such as antidepressants, and environmental agents, such as bisphenol A. Various types of studies can provide evidence to identify MDAs, yet a systematic method is needed to integrate these data
La Merrill MA, Smith MT, McHale CM, Heindel JJ, Atlas E, Cave MC, Collier D, Guyton KZ, Koliwad S, Nadal A, Rhodes CJ, Sargis RM, Zeise L, Blumberg B.   +13 more
europepmc   +4 more sources

Key Characteristics and Development of Psychoceuticals: A Review. [PDF]

Int J Mol Sci, 2022
Psychoceuticals have brought benefits to the pharmacotherapeutic management of central nervous system (CNS) illnesses since the 19th century. However, these drugs have potential side effects or lack high response rates. This review covers twenty drugs’ biochemical mechanisms, benefits, risks, and clinical trial reports. For this study, medications from
Cano GH, Dean J, Abreu SP, Rodríguez AH, Abbasi C, Hinson M, Lucke-Wold B.   +6 more
europepmc   +3 more sources

Effects of temperature and nitrogen application on photosynthetic characteristics and the absorption and distribution of carbon and nitrogen in apple plants

Photosynthetica, 2021
Low temperature has negative effects on apple photosynthesis by inhibiting the accumulations of photosynthates and nitrogen. The interactive effects of low temperature and nitrogen application on photosynthetic parameters and the absorption and ...
H.H. ZHANG, H.F. LIU, Z. LI, H.F. DING, Z.X. XUE, F.Y. ZHAO, S.L. YU, K. YU   +7 more
doaj   +1 more source

Research on 3D mechanical properties of sludge solidified soil under the action of drying and wetting cycles

Shuiwen dizhi gongcheng dizhi, 2021
A novel curing agent produced by our independent research and development is used to solidify the municipal sludge taken from Tianjin. GCTS true triaxial apparatus is used to conduct unconsolidated and undrained tests on the sludge solidified soil under ...
Jian XU, Xu ZHAO, Ruimin MA, Aiwu YANG, Shaokun YANG   +4 more
doaj   +1 more source

Comparative RNA-Seq analysis to understand anthocyanin biosynthesis and regulations in Curcuma alismatifolia

Folia Horticulturae, 2022
Anthocyanins play a critical role in flower colour pattern formation, and their biosynthesis is typically regulated by transcription factors (TFs). Curcuma alismatifolia is a well-known ornamental plant with colourful flowers.
Li Yuan-Yuan, Chen Xiao-Huang, Yu Hui-Wen, Tian Qi-Lin, Lu Luan-Mei   +4 more
doaj   +1 more source

Dynamic and structural characteristics of sludge solidified light soil under freezing-thawing action

Shuiwen dizhi gongcheng dizhi, 2022
Freezing-thawing action will affect the mechanical and structural characteristics of sludge solidified light soil. In order to study the dynamic characteristics and structural evolution of sludge solidified light soil under different freezing-thawing ...
Aiwu YANG, Binbin WANG, Xiaokai ZHONG
doaj   +1 more source

Key Characteristics of Hymns

Journal of Advanced Computational Intelligence and Intelligent Informatics, 2007
The authors propose a way of patterning the bars of monophonic melodies in hymns and finding keys from such patterns. The authors represent monophonic melody bars on a vector showing the duration of pitch chroma contained in each bar. In experiments, the authors patterned bars of 352 four/four beat hymns, defined the distance between the bar key and ...
Tatsuo Kamitani, Minoru Matsuda
openaire   +1 more source

3D seismic simulation analysis of the Longtoushan Town Basin during the 2014 Ludian earthquake, Yunnan province

Frontiers in Earth Science, 2023
On 3 August 2014, a magnitude Ms 6.5 earthquake struck Ludian County, Zhaotong City, Yunnan Province, causing grave losses of life and property in the Longtoushan Town Basin near the fault. In this study, a three-dimensional model of the Longtoushan Town
Chengcheng Li, Chengcheng Li, Peng Liu, Zhongxian Liu, Xiaoming Yuan, Yuan Tian, Hai Zhang, Zhenzhong Cao   +7 more
doaj   +1 more source