Results 51 to 60 of about 1,214,320 (245)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Implementing TontineCoin [PDF]

, 2020
One of the alternatives to proof-of-work (PoW) consensus protocols is proof-of- stake (PoS) protocols, which address its energy and cost related issues. But they suffer from the nothing-at-stake problem; validators (PoS miners) are bound to lose nothing ...
Pardeshi, Prashant
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Key considerations and recommendations for recruiting older adults in physical activity studies

BMC Medical Research Methodology
Background Despite substantial evidence supporting the benefits of physical activity (PA) for older adults, participation rates remain low due to physical, psychological, social, and institutional barriers.
Sunwoo Lee, Magdalena Cyma-Wejchenig, Veysel Alcan, Ana Morais, Antoine Langeard, Elpidio Attoh-Mensah, Eleni Epiphaniou, Melanie Mack, Sebahat Gözüm, Aysegul Ilgaz, Zaur Gasimov, Iuliia Pavlova, Rafał Stemplewski, Michael Brach   +13 more
doaj   +1 more source

Development of a New Tool for Writing Research Key Information in Plain Language

Health Literacy Research and Practice
Background: The complexity of research informed consent forms makes it hard for potential study participants to make informed consent decisions. In response, new rules for human research protection require informed consent forms to begin with a key ...
Sabrina Kurtz-Rossi, Ifechi Augusta Okonkwo, Ye Chen, Noe Dueñas, Timothy Bilodeau, Alice Rushforth, Andreas Klein   +6 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Using constructed value of information to identify key uncertainties for a decision tree analysis in iterative structured decision making

Conservation Science and Practice
Conservation decisions are sometimes delayed due to pervasive uncertainty and the perception that more information is needed before acting. However, postponing decisions can be costly, both financially due to extended research efforts and ecologically ...
Laura M. Keating‐Elske, James R.N. Glasier, Laura D. Burns, Julian R. Dupuis, Llewellyn Haines, Lacey Hébert, Justis Henault, Jennifer Heron, Jessica E. Linton, Zachary G. MacDonald, Felix A.H. Sperling, Robert A. Sissons   +11 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Improving working equine welfare in 'hard-win' situations, where gains are difficult, expensive or marginal. [PDF]

PLoS ONE, 2018
Brooke is a non-government organisation with working equine welfare programmes across Africa, Asia and Latin America. In 2014, staff from ten country programmes were asked to identify 'no-win' situations (subsequently reframed as 'hard-wins')-where ...
Joy Pritchard, Melissa Upjohn, Tamsin Hirson   +2 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source