Results 101 to 110 of about 550,568 (326)
The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry
Acta Chimica Slovenica, 2017 Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj +1 more source
The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. [PDF]
Elife, 2021 Plassart L +12 more
europepmc +1 more source
Advanced Engineering Materials, EarlyView.The study presents an efficient simulation approach for the polymer laser powder bed fusion process polymers process, validated with polyamide 12, polyamide 6, and polyetherketoneketone. It shows that inter layer time affects part density, with 90s yielding dense parts.
Claas Bierwisch +4 more
wiley +1 more source
A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery
Nature Communications, 2016 Delivery of siRNA to target cells is essential for in vivogene therapy. Here the authors demonstrate an oligonucleotide aptamer that targets therapeutic siRNA to a specific cell type.
Kewei Ren +6 more
doaj +1 more source
Two-beam nonlinear Kerr effect to stabilize laser frequency with sub-Doppler resolution
, 2012 Avoiding laser frequency drifts is a key issue in many atomic physics experiments. Several techniques have been developed to lock the laser frequency using sub-Doppler dispersive atomic lineshapes as error signals in a feedback loop.
Ackemann +9 more
core +1 more source
A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion
Advanced Engineering Materials, EarlyView.A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann +5 more
wiley +1 more source
Western Journal of Emergency Medicine, 2019 Introduction: Safe firearm storage is associated with a lower risk of firearm-related injury and death. Although providing firearm locking devices is a key component of firearm safety interventions, little is known about the types and characteristics of ...
Joseph A. Simonetti +5 more
doaj +1 more source
Nature Chemical Biology, 2018 G-protein-coupled receptors (GPCRs) are critically involved in signal transduction. Structural views of several GPCRs have recently been obtained, but the structural principles determining subtype selectivity are still mostly elusive. Now, a combined solid-state NMR and molecular-modeling approach reveals how bradykinin GPCRs distinguish between ...
openaire +4 more sources
Simulation of Inhomogeneous Refractive Index Fields Induced by Hot Tailored Forming Components
Advanced Engineering Materials, EarlyView.This article presents a simulation model for simulating inhomogeneous refractive index fields (IRIF) in hot‐forged components, accounting for thermal influences and complex geometries. Through this simulation, a priori knowledge about the propagation of the IRIF can be obtained, allowing for the positioning of the component or an optical measurement ...
Pascal Kern +3 more
wiley +1 more source
Carbon Lock-In Mechanisms in Transport Infrastructure and Temporal Spatial Dynamics
BuildingsThe persistent carbon lock-in in transport infrastructure hinders low-carbon transition and sustainable urban development. This study, situated within the context of building energy and systems environments, examines the spatial and temporal dynamics of ...
Yinghui Zhang +4 more
doaj +1 more source